SR 3576

JNK3 kinase inhibitor

Catalog No. SIH-513

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CAS No. 1164153-22-3
Molecular Formula C27H27N5O5
SKU: SIH-513 Categories: ,

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SIH-513_SR-3576_Chemical_Structure.png
Product Name SR 3576
Description

JNK3 kinase inhibitor

Purity >98% (HPLC)
CAS No. 1164153-22-3
Molecular Formula C27H27N5O5
Molecular Weight 501.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance Off White solid
InChI InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
InChIKey MTFAYLZZDJGFGV-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product SR 3576 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-513)

Biological Description

Alternative Names SR3576, 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 70702008
Scientific Background SR 3576 is a highly potent and selective inhibitor of c-Jun N-terminal kinase 3 (JNK3), a kinase predominantly expressed in the brain. JNK3 is involved in stress-induced neuronal apoptosis and is implicated in the pathogenesis of several neurodegenerative diseases. By inhibiting JNK3, SR 3576 offers a targeted approach to reduce neuronal death and has potential therapeutic value in conditions such as stroke, Alzheimer's disease, and traumatic brain injury.
References 1. Kamenecka T., et al. (2009) J. Biol. Chem. 284(19): 12853–12861.

Product Images

<p>Chemical structure of SR 3576 (SIH-513), a JNK3 kinase inhibitor. CAS #: 1164153-22-3. Molecular Formula: C27H27N5O5. Molecular Weight: 501.5 g/mol.</p>

Chemical structure of SR 3576 (SIH-513), a JNK3 kinase inhibitor. CAS #: 1164153-22-3. Molecular Formula: C27H27N5O5. Molecular Weight: 501.5 g/mol.

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