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| Product Name | SR 3576 |
| Description |
JNK3 kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 1164153-22-3 |
| Molecular Formula | C27H27N5O5 |
| Molecular Weight | 501.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | Off White solid |
| InChI | InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34) |
| InChIKey | MTFAYLZZDJGFGV-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | SR 3576 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-513) |
Biological Description
| Alternative Names | SR3576, 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 70702008 |
| Scientific Background | SR 3576 is a highly potent and selective inhibitor of c-Jun N-terminal kinase 3 (JNK3), a kinase predominantly expressed in the brain. JNK3 is involved in stress-induced neuronal apoptosis and is implicated in the pathogenesis of several neurodegenerative diseases. By inhibiting JNK3, SR 3576 offers a targeted approach to reduce neuronal death and has potential therapeutic value in conditions such as stroke, Alzheimer's disease, and traumatic brain injury. |
| References | 1. Kamenecka T., et al. (2009) J. Biol. Chem. 284(19): 12853–12861. |
Product Images
Chemical structure of SR 3576 (SIH-513), a JNK3 kinase inhibitor. CAS #: 1164153-22-3. Molecular Formula: C27H27N5O5. Molecular Weight: 501.5 g/mol.
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