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| Product Name | STO 609 |
| Description |
CAMKK kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 52029-86-4 |
| Molecular Formula | C21H14N2O5 |
| Molecular Weight | 374.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (10 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC(=O)O.C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O |
| InChI | InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4) |
| InChIKey | WNRSTFUVBWNELX-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | STO 609 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-479) |
Biological Description
| Alternative Names | 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 16760660 |
| Scientific Background | STO 609 is a potent, competitive and selective inhibitor of Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK). STO 609 has been shown to bind to the CaMKK catalytic domain, consequently inhibiting autophosphorylation. It is a valuable tool for exploring the role of the CaM-KK pathway in various physiological processes. STO 609 is cell-permeable. |
| References |
1. Tokumitsu, H., et al. (2002) J. Biol. Chem. 277(18): 15813–15818. 2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364. 3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388. |
Product Images
Chemical structure of STO 609 (SIH-479), a CAMKK kinase inhibitor. CAS #: 52029-86-4. Molecular Formula: C21H14N2O5. Molecular Weight: 374.3 g/mol.
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