STO 609

CAMKK kinase inhibitor

Catalog No. SIH-479

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CAS No. 52029-86-4
Molecular Formula C21H14N2O5
SKU: SIH-479 Categories: ,

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SIH-479_STO-609_Chemical_Structure.png
Product Name STO 609
Description

CAMKK kinase inhibitor

Purity >98% (TLC)
CAS No. 52029-86-4
Molecular Formula C21H14N2O5
Molecular Weight 374.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (10 mg/ml)
Source Synthetic
Appearance Yellow solid
SMILES CC(=O)O.C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O
InChI InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
InChIKey WNRSTFUVBWNELX-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product STO 609 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-479)

Biological Description

Alternative Names 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 16760660
Scientific Background STO 609 is a potent, competitive, and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase kinase (CaM-KK). It binds to the catalytic domain of CaMKK and inhibits its autophosphorylation. In neurodegenerative disease research, STO 609 is used to investigate calcium signaling pathways involved in neuronal plasticity, metabolism, and survival. CaMKK signaling is implicated in neuroinflammation and neurodegeneration, making STO 609 a valuable tool for dissecting calcium-dependent regulatory mechanisms in the brain. It is cell-permeable and widely used in both in vitro and in vivo models.
References 1. Tokumitsu, H., et al. (2002) J. Biol. Chem. 277(18): 15813–15818.
2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364.
3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.

Product Images

<p>Chemical structure of STO 609 (SIH-479), a CAMKK kinase inhibitor. CAS #: 52029-86-4. Molecular Formula: C21H14N2O5. Molecular Weight: 374.3 g/mol.</p>

Chemical structure of STO 609 (SIH-479), a CAMKK kinase inhibitor. CAS #: 52029-86-4. Molecular Formula: C21H14N2O5. Molecular Weight: 374.3 g/mol.

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