SU 4312

VEGFR, PDGFR kinase inhibitor

Catalog No. SIH-481

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CAS No. 07-07-12
Molecular Formula C17H16N2O
SKU: SIH-481 Categories: ,

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SIH-481_SU-4312_Chemical_Structure.png
Product Name SU 4312
Description

VEGFR, PDGFR kinase inhibitor

Purity >98% (HPLC)
CAS No. 07-07-12
Molecular Formula C17H16N2O
Molecular Weight 264.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (25 mg/ml)
Source Synthetic
Appearance Orange solid
SMILES C1=CC=CC3=C1C(=C/C2=CC=C(N(C)C)C=C2)/C(=O)N3
InChI InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
InChIKey UAKWLVYMKBWHMX-PTNGSMBKSA-N
Safety Phrases Classification:
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product SU 4312 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-481)

Biological Description

Alternative Names 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 6450842
Scientific Background SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases, including VEGFR-2 (Flk-1/KDR). In neurodegenerative disease research, SU 4312 is used to investigate the role of VEGF and PDGF signaling in neurovascular remodeling, glial activation, and neuronal survival. Its ability to modulate angiogenic and inflammatory pathways makes it a valuable tool for studying the vascular component of neurodegeneration and brain repair mechanisms.
References 1. Zaman G.J., et al. (1999) Biochem. Pharm. 57(1): 57–64.
2. Shimotake J., Derugin N., Wendland M., Vexler Z.S., & Ferriero D.M. (2010) Stroke. 41(2): 343–349.
3. Schultheiss C., et al. (2006) Angiogenesis. 9(2): 59–65.

Product Images

<p>Chemical structure of SU 4312 (SIH-481), a VEGFR / PDGFR kinase inhibitor. CAS #: 5812-07-7. Molecular Formula: C17H16N2O. Molecular Weight: 264.3 g/mol.</p>

Chemical structure of SU 4312 (SIH-481), a VEGFR / PDGFR kinase inhibitor. CAS #: 5812-07-7. Molecular Formula: C17H16N2O. Molecular Weight: 264.3 g/mol.

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