Sulindac Sulfide

COX inhibitor

Catalog No. SIH-261

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CAS No. 32004-67-4
Molecular Formula C20H17FO2S
SKU: SIH-261 Categories: ,

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SIH-261_Sulindac_Sulfide_Chemical_Structure.png
Product Name Sulindac Sulfide
Description

COX inhibitor

Purity >98%
CAS No. 32004-67-4
Molecular Formula C20H17FO2S
Molecular Weight 340.41
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 25 mM in DMSO, 3 mM in ethanol
Source Synthetic
Appearance Yellow solid
SMILES CC1=C(C2=C(/C1=CC3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O
InChI InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-
InChIKey LFWHFZJPXXOYNR-RQZCQDPDSA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R62 - Possible risk of impaired fertility
Hazard Phrases:
H302-H317-H334-H361
Precautionary Phrases:
P261-P280-P342 + P311
Cite This Product Sulindac Sulfide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-261)

Biological Description

Alternative Names {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid
Research Areas Apoptosis, Cancer
PubChem ID 1548887
Scientific Background Sulindac sulfide is the active metabolite of the nonsteroidal anti-inflammatory drug (NSAID) sulindac. It exerts its effects by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis and inflammation. In neuroscience, sulindac sulfide has been investigated for its ability to induce apoptosis in abnormal cells and modulate neuroinflammatory pathways. Its potential to reduce oxidative stress and inflammation makes it a candidate for neuroprotective strategies in neurodegenerative diseases.
References 1. Frahm S., et al. (2004) Cancer Cell Int. 4:4.
2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.

Product Images

<p>Chemical structure of Sulindac Sulfide (SIH-261), a NFkB inhibitor. CAS #: 32004-67-4. Molecular Formula: C20H17FO2S . Molecular Weight: 340.41 g/mol.</p>

Chemical structure of Sulindac Sulfide (SIH-261), a NFkB inhibitor. CAS #: 32004-67-4. Molecular Formula: C20H17FO2S . Molecular Weight: 340.41 g/mol.

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