Discovery through Partnership | Excellence through Quality
| Product Name | Sulindac Sulfide |
| Description |
COX inhibitor |
| Purity | >98% |
| CAS No. | 32004-67-4 |
| Molecular Formula | C20H17FO2S |
| Molecular Weight | 340.41 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 25 mM in DMSO, 3 mM in ethanol |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC1=C(C2=C(/C1=CC3=CC=C(C=C3)SC)C=CC(=C2)F)CC(=O)O |
| InChI | InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17- |
| InChIKey | LFWHFZJPXXOYNR-RQZCQDPDSA-N |
| Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R62 - Possible risk of impaired fertility Hazard Phrases: H302-H317-H334-H361 Precautionary Phrases: P261-P280-P342 + P311 |
| Cite This Product | Sulindac Sulfide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-261) |
Biological Description
| Alternative Names | {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 1548887 |
| Scientific Background | Sulindac sulfide is the active metabolite of the nonsteroidal anti-inflammatory drug (NSAID) sulindac. It exerts its effects by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis and inflammation. In neuroscience, sulindac sulfide has been investigated for its ability to induce apoptosis in abnormal cells and modulate neuroinflammatory pathways. Its potential to reduce oxidative stress and inflammation makes it a candidate for neuroprotective strategies in neurodegenerative diseases. |
| References |
1. Frahm S., et al. (2004) Cancer Cell Int. 4:4. 2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459. |
Product Images
Chemical structure of Sulindac Sulfide (SIH-261), a NFkB inhibitor. CAS #: 32004-67-4. Molecular Formula: C20H17FO2S . Molecular Weight: 340.41 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.