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| Product Name | Sunitinib malate |
| Description |
VEGFR, PDGFR kinase inhibitor |
| Purity | >99% |
| CAS No. | 557795-19-4 |
| Molecular Formula | C22H27FN4O2 |
| Molecular Weight | 398.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (40 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C1=CC2=C(C=C1F)C(/C(N2)=O)=C/C3=C(C(=C([NH]3)C)C(NCCN(CC)CC)=O)C |
| InChI | InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- |
| InChIKey | WINHZLLDWRZWRT-ATVHPVEESA-N |
| Safety Phrases |
Classification: Reproductive toxicity (Category 1B), H360 Specific target organ toxicity-repeated exposure, Oral (Category 1), H372 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure if swallowed. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P405 Store locked up. |
| Cite This Product | Sunitinib malate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-482) |
Biological Description
| Alternative Names | N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5329102 |
| Scientific Background | Sunitinib malate is a receptor tyrosine kinase inhibitor that targets multiple kinases including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α, PDGFR-β, KIT, FLT3, CSF-1R, and RET. In neuroscience, Sunitinib is used to study neurovascular signaling, glial activation, and neuroinflammation. Its broad-spectrum kinase inhibition profile makes it suitable for exploring the interplay between angiogenesis, immune responses, and neuronal survival in neurodegenerative disease models. Sunitinib is also being investigated for its potential to modulate blood-brain barrier function and tumor angiogenesis in brain cancers. |
| References | 1. Hersey P., et al. (2009) Annals of Oncology: ESMO. 20 Suppl 6: vi35–40. |
Product Images
Chemical structure of Sunitinib malate (SIH-482), a VEGFR, PDGFR kinase inhibitor. CAS #: 557795-19-4. Molecular Formula: C22H27FN4O2. Molecular Weight: 398.5 g/mol.
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