Sunitinib malate

VEGFR, PDGFR kinase inhibitor

Catalog No. SIH-482

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CAS No. 557795-19-4
Molecular Formula C22H27FN4O2
SKU: SIH-482 Categories: ,

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SIH-482_Sunitinib_malate_Chemical_Structure.png
Product Name Sunitinib malate
Description

VEGFR, PDGFR kinase inhibitor

Purity >99%
CAS No. 557795-19-4
Molecular Formula C22H27FN4O2
Molecular Weight 398.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (40 mg/ml)
Source Synthetic
Appearance Yellow solid
SMILES C1=CC2=C(C=C1F)C(/C(N2)=O)=C/C3=C(C(=C([NH]3)C)C(NCCN(CC)CC)=O)C
InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
InChIKey WINHZLLDWRZWRT-ATVHPVEESA-N
Safety Phrases Classification:
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity-repeated exposure, Oral (Category 1), H372

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H360 May damage fertility or the unborn child.
H372 Causes damage to organs through prolonged or repeated exposure if swallowed.

Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P405 Store locked up.
Cite This Product Sunitinib malate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-482)

Biological Description

Alternative Names N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 5329102
Scientific Background Sunitinib malate is a receptor tyrosine kinase inhibitor that targets multiple kinases including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α, PDGFR-β, KIT, FLT3, CSF-1R, and RET. In neuroscience, Sunitinib is used to study neurovascular signaling, glial activation, and neuroinflammation. Its broad-spectrum kinase inhibition profile makes it suitable for exploring the interplay between angiogenesis, immune responses, and neuronal survival in neurodegenerative disease models. Sunitinib is also being investigated for its potential to modulate blood-brain barrier function and tumor angiogenesis in brain cancers.
References 1. Hersey P., et al. (2009) Annals of Oncology: ESMO. 20 Suppl 6: vi35–40.

Product Images

<p>Chemical structure of Sunitinib malate (SIH-482), a VEGFR, PDGFR kinase inhibitor. CAS #: 557795-19-4. Molecular Formula: C22H27FN4O2. Molecular Weight: 398.5 g/mol.</p>

Chemical structure of Sunitinib malate (SIH-482), a VEGFR, PDGFR kinase inhibitor. CAS #: 557795-19-4. Molecular Formula: C22H27FN4O2. Molecular Weight: 398.5 g/mol.

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