TCID

DUB inhibitor

Catalog No. SIH-340

0 out of 5 based on 0 customer ratings
CAS No. 30675-13-9
Molecular Formula C9H2Cl4O2
SKU: SIH-340 Categories: ,

Clear
SIH-340_TCID_Chemical_Structure.png
Product Name TCID
Description

DUB inhibitor

Purity >97%
CAS No. 30675-13-9
Molecular Formula C9H2Cl4O2
Molecular Weight 283.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO
Source Synthetic
Appearance White Solid
SMILES C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
InChI InChI=1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
InChIKey IDLAOWFFKWRNHB-UHFFFAOYSA-N
Safety Phrases Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Precautionary Statements:
P260- Do not breathe dust/fume/gas/mist/vapours/spray.
P285- In case of inadequate ventilation wear respiratory protection.
P305+P351+P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310- Immediately call a POISON CENTER or doctor/physician.
P501- Dispose of contents/container in accordance with international regulations.
Hazard Statements:
H334- May cause allergy or asthma symptoms or breathing difficulties if inhaled
H373- May cause damage to organs through prolonged or repeated exposure
H318- Causes serious eye damage
H410- Very toxic to aquatic life with long lasting effects
H317- May cause an allergic skin reaction
Cite This Product TCID (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-340)

Biological Description

Alternative Names 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
Research Areas Apoptosis, Cancer
PubChem ID 2729042
Scientific Background TCID is a cell-permeable inhibitor of ubiquitin C-terminal hydrolase L3 (UCHL3), with an IC50 of 0.6 µM and high selectivity over UCHL1. UCHL3 is involved in the processing of ubiquitin precursors and the recycling of ubiquitin from substrates, playing a critical role in maintaining ubiquitin homeostasis. In the context of neurodegeneration, dysregulation of deubiquitinating enzymes like UCHL3 may contribute to protein aggregation and neuronal dysfunction. TCID serves as a chemical probe to dissect the role of UCHL3 in neuronal systems and may support the development of targeted therapies for diseases involving ubiquitin pathway dysregulation.
References 1. Love K.R., et al. (2007) Nat. Chem. Biol. 3: 697.
2. Mtango N.R. et al. (2012) J. Cell Physiol. 227: 2022.

Product Images

<p>Chemical structure of TCID (SIH-340), a DUB inhibitor. CAS #: 30675-13-9. Molecular Formula: C9H2Cl4O2. Molecular Weight: 283.9 g/mol.</p>

Chemical structure of TCID (SIH-340), a DUB inhibitor. CAS #: 30675-13-9. Molecular Formula: C9H2Cl4O2. Molecular Weight: 283.9 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “TCID”

Your email address will not be published. Required fields are marked *