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| Product Name | Thalidomide |
| Description |
E3 UB ligase inhibitor |
| Purity | >98% |
| CAS No. | 50-35-1 |
| Molecular Formula | C13H10N2O4 |
| Molecular Weight | 258.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 5 mg/ml DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O |
| InChI | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) |
| InChIKey | UEJJHQNACJXSKW-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Very toxic material causing immediate and serious toxic effects. Highly toxic teratogen. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – Harmful if swallowed H360 – May damage fertility or the unborn child Precautionary Statements: P201 – Obtain special instructions before use. P308 + P313 – If exposed or concerned: Get medical advice/ attention. |
| Cite This Product | Thalidomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-336) |
Biological Description
| Alternative Names | (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, N-(2,6-dioxo-3-piperidinyl)phthalimide |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5426 |
| Scientific Background | Thalidomide binds to the E3 ubiquitin ligase complex involving CRBN, DDB1, and Cul4A, inhibiting ligase activity. It suppresses TNF synthesis and angiogenesis. In neuroscience, Thalidomide is explored for its immunomodulatory effects and potential to modulate neuroinflammation and neurovascular integrity, although caution is warranted due to its teratogenic properties. |
| References |
1. Ito T., et al. (2010) Science. 327:1345. 2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195. 3. D’Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082. |
Product Images
Chemical structure of Thalidomide (SIH-336), a E3 UB ligase inhibitor. CAS #: 50-35-1. Molecular Formula: C13H10N2O4. Molecular Weight: 258.2 g/mol.
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