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| Product Name | Thiolutin |
| Description |
RNA polymerase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 87-11-6 |
| Molecular Formula | C8H8N2O2S2 |
| Molecular Weight | 228.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (15 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow powder |
| SMILES | CC(=O)NC1=C2C(=CSS2)N(C1=O)C |
| InChI | InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11) |
| InChIKey | MHMRAFONCSQAIA-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Danger. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H300 – Fatal if swallowed H330 – Fatal if inhaled Precautionary Phrases: P260 – Do not breathe dust/fume/gas/mist/vapours/spray P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P405 – Store locked up |
| Cite This Product | Thiolutin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-375) |
Biological Description
| Alternative Names | N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl)acetamide |
| Research Areas | Cell Signaling |
| PubChem ID | 6870 |
| Scientific Background | Thiolutin is a sulfur-containing antibiotic that inhibits RNA polymerases and has been shown to block transcription initiation. In neuroscience, it is used to study transcriptional regulation and stress responses in neurons. Thiolutin also exhibits antioxidant properties and can modulate proteasome activity, making it relevant in models of oxidative stress and protein aggregation. These features are particularly important in neurodegenerative diseases where transcriptional dysregulation and oxidative damage contribute to neuronal loss. |
| References |
1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92. 2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165. 3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307. |
Product Images
Chemical structure of Thiolutin (SIH-375), a HSP27 perturbing agent. CAS #: 87-11-6. Molecular Formula: C8H8N2O2S2. Molecular Weight: 228.3 g/mol.
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