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| Product Name | TOFA |
| Description |
Acetyl-CoA Carboxylase Inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 54857-86-2 |
| Molecular Formula | C19H32O4 |
| Molecular Weight | 324.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Blue Ice or 4ºC |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (15 mg/ml); or ethanol (9 mg/ml) |
| Source | Synthetic |
| Appearance | White crystalline powder |
| SMILES | CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O |
| InChI | InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21) |
| InChIKey | CZRCFAOMWRAFIC-UHFFFAOYSA-N |
| Safety Phrases |
WHMIS Classification: Not WHMIS controlled. Not a dangerous substance according to GHS. HMIS Classification: Health hazard: 0 Flammability: 0 Physical hazards: 0 Potential Health Effects: Inhalation - May be harmful if inhaled. May cause respiratory tract irritation. Skin - May be harmful if absorbed through skin. May cause skin irritation. Eyes - May cause eye irritation. Ingestion - May be harmful if swallowed. |
| Cite This Product | TOFA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-555) |
Biological Description
| Alternative Names | 5-(Tetradecyloxy)-2-furoic acid, RMI-14514, 5-tetradecoxyfuran-2-carboxylic acid |
| Research Areas | Cell Signaling, Metabolism, Redox Metabolism |
| PubChem ID | 115175 |
| Scientific Background | TOFA is an acetyl-CoA carboxylase (ACC) inhibitor that disrupts fatty acid synthesis. While not widely cited in neurodegenerative disease research, TOFA is frequently used in metabolic and cancer biology to study lipid metabolism. Its relevance to neuroscience may emerge through investigations into lipid dysregulation in neurodegenerative disorders, where altered lipid synthesis and energy metabolism contribute to disease progression. |
Product Images
Chemical structure of TOFA (SIH-555), a Ac-CoA carboxylase inhibitor. CAS #: 54857-86-2. Molecular Formula: C19H32O4. Molecular Weight: 324.5 g/mol.
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