Tranilast

Angiogenesis inhibitor

Catalog No. SIH-369

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CAS No. 53902-12-8
Molecular Formula C18H17NO5
SKU: SIH-369 Categories: ,

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SIH-369_Tranilast_Chemical_Structure.png
Product Name Tranilast
Description

Angiogenesis inhibitor

Purity >95% (HPLC)
CAS No. 53902-12-8
Molecular Formula C18H17NO5
Molecular Weight 327.33
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO.
Source Synthetic
Appearance Off-white to yellow powder.
SMILES COC1=C(C=C(C=C1)/C=C/C(=O)NC2=CC=CC=C2C(=O)O)OC
InChI InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChIKey NZHGWWWHIYHZNX-CSKARUKUSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302 – Harmful if swallowed.
H312 – Harmful in contact with skin.
H332 – Harmful if inhaled.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray
P280 – Wear protective gloves/protective clothing/eye protection/face protection.
P301+ P312 IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304+P340 – IF INHALED: remove victim to fresh air and keep at rest in a position comfortable for breathing.
P501 – Dispose of contents/container in accordance with local/regional/national/ international regulations.
Cite This Product Tranilast (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-369)

Biological Description

Alternative Names 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2- enoyl]amino}benzoic acid
Research Areas Cancer, Cardiovascular System, Cell Signaling, Neuroscience
PubChem ID 5282230
Scientific Background Tranilast is an antiallergic and antifibrotic compound increasingly explored in neurodegenerative disease research for its ability to modulate inflammatory and fibrotic pathways. It inhibits collagen synthesis in a dose-dependent manner and suppresses transforming growth factor-beta (TGF-β), a cytokine implicated in neuroinflammation and glial scarring. These properties suggest potential therapeutic relevance in conditions such as multiple sclerosis and Alzheimer’s disease, where fibrosis and chronic inflammation contribute to disease progression. While traditionally used in allergy and oncology research, Tranilast’s emerging role in modulating neuroimmune responses positions it as a candidate for repurposing in neuroprotective strategies.
References 1. Yamada H., Tajima S., Nishikawa T., Murad S., and Pinnell S., (1999) The Journal of Biochemistrystry. 116(4): 892-897.
2. Chakrabarti R., Subramanian V., Abadalla J., Jothy S., Predhomme GJ. (2009) Anticancer Drugs. 20(5): 334-45.

Product Images

<p>Chemical structure of Tranilast (SIH-369), a Angiogenesis inhibitor. CAS #: 53902-12-8. Molecular Formula: C18H17NO5  . Molecular Weight: 327.33 g/mol.</p>

Chemical structure of Tranilast (SIH-369), a Angiogenesis inhibitor. CAS #: 53902-12-8. Molecular Formula: C18H17NO5 . Molecular Weight: 327.33 g/mol.

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