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| Product Name | Triacsin C |
| Description |
Acyl-CoA synthetase inhibitor |
| Purity | 90% (HPLC); NMR (Conforms) |
| CAS No. | 76896-80-5 |
| Molecular Formula | C11H17N3O |
| Molecular Weight | 207.27 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml) or methanol (5 mg/ml) |
| Source | Synthetic |
| Appearance | Oil dissolved in DMSO (1mg/ml) |
| SMILES | CCC/C=C/C/C=C/C=C/C=N/NN=O |
| InChI | InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+ |
| InChIKey | NKTGCVUIESDXPU-YLEPRARLSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Triacsin C (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-203) |
Biological Description
| Alternative Names | (3E)-1-Oxo-3-[(2E,4E,7E)-2,4,7-undecatrien-1-ylidene]triazane |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 9576787 |
| Scientific Background | Triacsin C is a potent inhibitor of long-chain fatty acyl-CoA synthetase, an enzyme involved in lipid metabolism. By blocking the synthesis of triglycerides, diglycerides, and cholesterol esters, Triacsin C disrupts lipid signaling pathways implicated in neurodegeneration. It has been shown to prevent beta-cell apoptosis and exhibits vasodilatory properties. In the context of neuroscience, Triacsin C is used to study the role of lipid metabolism in neuronal survival, inflammation, and synaptic function, particularly in diseases like Alzheimer's and Parkinson's. |
| References | 1. Igal R.A., Wang P., Coleman R.A. (1997) Biochem J. 324(Pt2): 529-534. |
Product Images
Chemical structure of Triacsin C (SIH-203), a Fatty acyl-CoA synthase inhibitor. CAS #: 76896-80-5. Molecular Formula: C11H17N3O . Molecular Weight: 207.27 g/mol.
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Based on validation through cited publications.