U0126

MEK inhibitor

Catalog No. SIH-380

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CAS No. 109511-58-2
Molecular Formula C18H16N6S2
SKU: SIH-380 Categories: ,

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SIH-380_U-0126_Chemical_Structure.png
Product Name U0126
Description

MEK inhibitor

Purity >98%
CAS No. 109511-58-2
Molecular Formula C18H16N6S2
Molecular Weight 380.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (>10 mg/ml), 100% ethanol (2 mg/ml)
Source Synthetic
Appearance White solid
SMILES C2=C(SC(/N)=C(/C(=C(SC1=CC=CC=C1N)N)C#N)C#N)C(=CC=C2)N
InChI InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChIKey DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product U-0126 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-380)

Biological Description

Alternative Names 1,4-Diamino-2,3-dicyano-1,4-bis[2-a­minophenylthio]butadiene
Research Areas Cell Signaling
PubChem ID 3006531
Scientific Background U-0126 is a selective and non-competitive inhibitor of MEK1 and MEK2 (IC50 = 72 nM and 58 nM, respectively), key kinases in the MAPK/ERK signaling cascade. This pathway regulates cell proliferation, differentiation, and survival—processes often dysregulated in neurodegenerative diseases. U-0126 is widely used in neuroscience to investigate ERK-dependent mechanisms of synaptic plasticity, memory formation, and neuronal survival. It also inhibits AP-1 transcriptional activity and suppresses the production of inflammatory cytokines and matrix metalloproteinases, linking it to studies on neuroinflammation and glial activation. U-0126’s ability to induce apoptosis under growth factor deprivation conditions further supports its use in modeling neurodegenerative stress responses. Its fluorescence properties in cell culture also make it a useful marker in imaging-based assays.
References 1. Duncia J.V., et a.l (1998) Bioorg. Med. Chem. Lett. 8(20): 2839-44.
2. Favata M.F., et al. (1998) J. Biol. Chem. 273(29): 18623-32.
3. Davies S.P., et al. (2000) Biochem. J. 351(Pt1): 95-105.
4. Namura S., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(20): 11569-74.

Product Images

<p>Chemical structure of U-0126 (SIH-380), a MEK inhibitor. CAS #: 109511-58-2. Molecular Formula: C18H16N6S2. Molecular Weight: 380.5 g/mol.</p>

Chemical structure of U-0126 (SIH-380), a MEK inhibitor. CAS #: 109511-58-2. Molecular Formula: C18H16N6S2. Molecular Weight: 380.5 g/mol.

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