U-74389G

Lipid peroxidation blocker

Catalog No. SIH-205

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CAS No. 153190-29-5
Molecular Formula C37H50N6O2•C4H4O4
SKU: SIH-205 Categories: ,

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SIH-205_U-74389G_Chemical_Structure.png
Product Name U-74389G
Description

Lipid peroxidation blocker

Purity >99%
CAS No. 153190-29-5
Molecular Formula C37H50N6O2•C4H4O4
Molecular Weight 726.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO, and in 20 mg/ml in ethanol; Insoluble in water
Source Synthetic
Appearance White Solid
SMILES C[C@]12CC=C3[C@H]([C@@H]1CC[C@@H]2C(=O)CN4CCN(CC4)C5=NC(=NC(=C5)N6CCCC6)N7CCCC7)CCC8=CC(=O)C=C[C@@]83C.C(=CC(=O)O)C(=O)O
InChI InChI=1S/C37H50N6O2.CH4O3S/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-
InChIKey QZGBZPCDCMUFCW-FRVIMOPGSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product U-74389G (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-205)

Biological Description

Alternative Names 21-{4-[2,6-Di(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-2-butenedioate (1:1)
Research Areas Apoptosis, Cancer
PubChem ID 104933
Scientific Background U-74389G is a potent antioxidant that prevents iron-dependent lipid peroxidation, a key contributor to neuronal damage in ischemia-reperfusion injury. It has been studied for its protective effects in organ preservation and reperfusion models. In neuroscience, U-74389G is of interest for its ability to reduce oxidative stress and preserve neuronal integrity in models of stroke and traumatic brain injury. Its mechanism of action involves stabilizing cell membranes and preventing lipid peroxidation-induced apoptosis.
References 1. Ishizaki N., et al. (1997) Transplantation. 63: 202-208.
2. Perna A.M., et al. (1996) Pharmacol Res. 34: 25-31.
3. Palma-Vargas J.M., et al. (1996) J Surg Res. 66: 131-137.
4. Shoskes D.A., Xie Y., Gonzalez-Cadavid N.F. Transplantation. 63: 495-500.

Product Images

<p>Chemical structure of U-74389G (SIH-205), a Free radical scavenger. CAS #: 153190-29-5. Molecular Formula: C37H50N6O2 · C4H4O4 . Molecular Weight: 726.9 g/mol.</p>

Chemical structure of U-74389G (SIH-205), a Free radical scavenger. CAS #: 153190-29-5. Molecular Formula: C37H50N6O2 · C4H4O4 . Molecular Weight: 726.9 g/mol.

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