Product Name | U-74389G |
Description |
Lipid peroxidation blocker |
Purity | >99% |
CAS No. | 153190-29-5 |
Molecular Formula | C37H50N6O2•C4H4O4 |
Molecular Weight | 726.9 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Inhibitor |
Solubility | Soluble in 25 mg/ml DMSO, and in 20 mg/ml in ethanol; Insoluble in water |
Source | Synthetic |
Appearance | White Solid |
SMILES | C[C@]12CC=C3[C@H]([C@@H]1CC[C@@H]2C(=O)CN4CCN(CC4)C5=NC(=NC(=C5)N6CCCC6)N7CCCC7)CCC8=CC(=O)C=C[C@@]83C.C(=CC(=O)O)C(=O)O |
InChI | InChI=1S/C37H50N6O2.CH4O3S/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20- |
InChIKey | QZGBZPCDCMUFCW-FRVIMOPGSA-N |
Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
Cite This Product | U-74389G (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-205) |
Alternative Names | 21-{4-[2,6-Di(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-2-butenedioate (1:1) |
Research Areas | Apoptosis, Cancer |
PubChem ID | 104933 |
Scientific Background | U-74389G is a potent antioxidant that prevents iron-dependent lipid peroxidation, a key contributor to neuronal damage in ischemia-reperfusion injury. It has been studied for its protective effects in organ preservation and reperfusion models. In neuroscience, U-74389G is of interest for its ability to reduce oxidative stress and preserve neuronal integrity in models of stroke and traumatic brain injury. Its mechanism of action involves stabilizing cell membranes and preventing lipid peroxidation-induced apoptosis. |
References |
1. Ishizaki N., et al. (1997) Transplantation. 63: 202-208. 2. Perna A.M., et al. (1996) Pharmacol Res. 34: 25-31. 3. Palma-Vargas J.M., et al. (1996) J Surg Res. 66: 131-137. 4. Shoskes D.A., Xie Y., Gonzalez-Cadavid N.F. Transplantation. 63: 495-500. |
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