Vandetanib

VEGFRK inhibitor

Catalog No. SIH-483

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CAS No. 443913-73-3
Molecular Formula C22H24BrFN4O2
SKU: SIH-483 Categories: ,

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SIH-483_Vandetinib_Chemical_Structure.png
Product Name Vandetanib
Description

VEGFRK inhibitor

Purity >98% (HPLC)
CAS No. 443913-73-3
Molecular Formula C22H24BrFN4O2
Molecular Weight 475.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (30 mg/ml) or EtOH (10 mg/ml)
Source Synthetic
Appearance Yellow solid
SMILES C1=C3C(=CC(=C1OC)OCC2CCN(CC2)C)N=CN=C3NC4=CC=C(Br)C=C4F
InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
InChIKey UHTHHESEBZOYNR-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Vandetanib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-483)

Biological Description

Alternative Names N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Growth Factor Receptor Inhibitors
PubChem ID 3081361
Scientific Background Vandetanib is a selective inhibitor of VEGFR2 (Flk-1) and VEGFR3 (Flt-4), both of which are involved in angiogenesis and lymphangiogenesis. In neurodegenerative disease research, Vandetanib is used to study the role of VEGF signaling in neurovascular integrity, inflammation, and neuronal survival. Its ability to modulate vascular permeability and glial responses makes it a valuable compound for investigating vascular contributions to neurodegeneration and CNS repair.
References 1. Bruns C.J., et al. (2000) Clin. Cancer. Res: J. Am. Assoc. Cancer Res. 6(5): 1936–1948.

Product Images

<p>Chemical structure of Vandetinib (SIH-483), a VEGFRK inhibitor. CAS #: 443913-73-3. Molecular Formula: C22H24BrFN4O2. Molecular Weight: 475.4 g/mol.</p>

Chemical structure of Vandetinib (SIH-483), a VEGFRK inhibitor. CAS #: 443913-73-3. Molecular Formula: C22H24BrFN4O2. Molecular Weight: 475.4 g/mol.

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