Vatalanib Dihydrochloride

VEGFR Tyrosine Kinase Inhibitor

Catalog No. SIH-484

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CAS No. 212141-51-0
Molecular Formula C20H17Cl3N4
SKU: SIH-484 Categories: ,

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SIH-484_Vatalanib_Dihydrochloride_Chemical_Structure.png
Product Name Vatalanib Dihydrochloride
Description

VEGFR Tyrosine Kinase Inhibitor

Purity 96%
CAS No. 212141-51-0
Molecular Formula C20H17Cl3N4
Molecular Weight 419.7
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (30 mg/ml), ethanol (10 mg/ml) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/ml )
Source Synthetic
Appearance Solid
SMILES C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
InChI InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
InChIKey AZUQEHCMDUSRLH-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Vatalanib Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-484)

Biological Description

Alternative Names N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Growth Factor Receptor Inhibitors
PubChem ID 22386467
Scientific Background Vatalanib Dihydrochloride is an inhibitor of Flk, c-Kit, and PDGFR-β, with demonstrated activity against VEGFR-dependent angiogenesis and EGFR- and RET-mediated tumor cell proliferation. In neuroscience, Vatalanib is used to explore the role of angiogenic and growth factor signaling in neurodegenerative diseases. Its ability to modulate vascular and glial responses makes it a useful tool for studying neuroinflammation, blood-brain barrier dysfunction, and tumor progression in the CNS.
References 1. Herbst R.S., Heymach J.V., O’Reilly M. S., Onn A., & Ryan A.J. (2007) Expert Opin. Invest. Drugs. 16(2): 239–249.

Product Images

<p>Chemical structure of Vatalanib Dihydrochloride (SIH-484), a VEGFRK inhibitor. CAS #: 212141-51-0. Molecular Formula: C20H17Cl3N4. Molecular Weight: 419.7 g/mol.</p>

Chemical structure of Vatalanib Dihydrochloride (SIH-484), a VEGFRK inhibitor. CAS #: 212141-51-0. Molecular Formula: C20H17Cl3N4. Molecular Weight: 419.7 g/mol.

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