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| Product Name | Vinblastine sulfate |
| Description |
Cell cycle blocker |
| Purity | >98% |
| CAS No. | 143-67-9 |
| Molecular Formula | C46H58N4O9•H2SO4 |
| Molecular Weight | 909.1 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO, methanol or water (25 mg/ml). |
| Source | Synthetic |
| Appearance | White powder. |
| SMILES | [C@@]178[C@@H](N(C2=C1C=C(C(=C2)OC)[C@@]5(C3=C(C4=C([NH]3)C=CC=C4)CCN6C[C@@H](C5)C[C@](O)(C6)CC)C(OC)=O)C)[C@](O)([C@H](OC |
| InChI | InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3) |
| InChIKey | KDQAABAKXDWYSZ-PNYVAJAMSA-N |
| Safety Phrases |
Classification: D1B- Toxic Material Causing Immediate and Serious Toxic Effects, Toxic by ingestion, D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant, Mutagen Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H315- Causes skin irritation. H318- Causes serious eye damage. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P280- Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | Vinblastine sulfate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-407) |
Biological Description
| Alternative Names | Vincaleukoblastine |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 5388983 |
| Scientific Background | Vinblastine sulfate is a microtubule-disrupting agent that binds to tubulin and inhibits microtubule polymerization. In neuroscience, it is used to study axonal transport, mitotic arrest, and neuronal morphology. Microtubule dynamics are essential for neuronal function, and their disruption is implicated in neurodegenerative diseases such as Alzheimer’s and ALS. Vinblastine serves as a tool to investigate cytoskeletal integrity, intracellular trafficking, and neurotoxicity mechanisms. |
| References |
1. Veldhoen R.A., et al. (2013) Oncogene. 32(6): 736-46. 2. Adiseshaiah P.P., et al. (2013) Cancer Lett. 337(2): 254-65. |
Product Images
Chemical structure of Vinblastine sulfate (SIH-407), a Microtubule assembly inhibitor. CAS #: 143-67-9. Molecular Formula: C46H58N4O9 . H2SO4. Molecular Weight: 909.1 g/mol.
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