Vismodegib

Hedgehog inhibitor

Catalog No. SIH-565

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CAS No. 879085-55-9
Molecular Formula C19H14Cl2N2O3S
SKU: SIH-565 Categories: ,

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SIH-565-Vismodegib-Chemical-Structure.png
Product Name Vismodegib
Description

Hedgehog inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 879085-55-9
Molecular Formula C19H14Cl2N2O3S
Molecular Weight 421.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (200 mg/ml); or ethanol (10 mg/ml, warm)
Source Synthetic
Appearance Off-white powder
SMILES CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChI InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
InChIKey BPQMGSKTAYIVFO-UHFFFAOYSA-N
Safety Phrases GHS Classification: GHS08 health hazard
Repr. 2 H361 Suspected of damaging fertility or the unborn child.
STOT RE 2 H373 May cause damage to organs through prolonged or repeated exposure.

Signal word: Warning

Hazard statements:
H361 Suspected of damaging fertility or the unborn child.
H373 May cause damage to organs through prolonged or repeated exposure.

Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international regulations.
Cite This Product Vismodegib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-565)

Biological Description

Alternative Names Vismodegib; 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Research Areas Cancer, Tumor suppressors
PubChem ID 24776445
Scientific Background Vismodegib is a selective inhibitor of the Hedgehog signaling pathway via Smoothened (SMO) receptor antagonism. While primarily used in oncology, Vismodegib has emerging applications in neuroscience, particularly in studies of neural development, stem cell maintenance, and glioblastoma. Dysregulation of Hedgehog signaling has been implicated in neurodevelopmental disorders and brain tumors. Vismodegib is used to dissect the role of this pathway in neural stem cell proliferation, differentiation, and tumorigenesis.

Product Images

<p>Chemical structure of Vismodegib (SIH-565), a Hedgehog inhibitor. CAS #: 879085-55-9. Molecular Formula: C19H14Cl2N2O3S. Molecular Weight: 421.3 g/mol.</p>

Chemical structure of Vismodegib (SIH-565), a Hedgehog inhibitor. CAS #: 879085-55-9. Molecular Formula: C19H14Cl2N2O3S. Molecular Weight: 421.3 g/mol.

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