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| Product Name | Vismodegib |
| Description |
Hedgehog inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 879085-55-9 |
| Molecular Formula | C19H14Cl2N2O3S |
| Molecular Weight | 421.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (200 mg/ml); or ethanol (10 mg/ml, warm) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl |
| InChI | InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24) |
| InChIKey | BPQMGSKTAYIVFO-UHFFFAOYSA-N |
| Safety Phrases |
GHS Classification: GHS08 health hazard Repr. 2 H361 Suspected of damaging fertility or the unborn child. STOT RE 2 H373 May cause damage to organs through prolonged or repeated exposure. Signal word: Warning Hazard statements: H361 Suspected of damaging fertility or the unborn child. H373 May cause damage to organs through prolonged or repeated exposure. Precautionary statements: P260 Do not breathe dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P308+P313 IF exposed or concerned: Get medical advice/attention. P314 Get medical advice/attention if you feel unwell. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. |
| Cite This Product | Vismodegib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-565) |
Biological Description
| Alternative Names | Vismodegib; 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691 |
| Research Areas | Cancer, Tumor suppressors |
| PubChem ID | 24776445 |
| Scientific Background | Vismodegib is a selective inhibitor of the Hedgehog signaling pathway via Smoothened (SMO) receptor antagonism. While primarily used in oncology, Vismodegib has emerging applications in neuroscience, particularly in studies of neural development, stem cell maintenance, and glioblastoma. Dysregulation of Hedgehog signaling has been implicated in neurodevelopmental disorders and brain tumors. Vismodegib is used to dissect the role of this pathway in neural stem cell proliferation, differentiation, and tumorigenesis. |
Product Images
Chemical structure of Vismodegib (SIH-565), a Hedgehog inhibitor. CAS #: 879085-55-9. Molecular Formula: C19H14Cl2N2O3S. Molecular Weight: 421.3 g/mol.
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