WHI P131

JAK3 kinase inhibitor

Catalog No. SIH-485

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CAS No. 202475-60-3
Molecular Formula C16H15N3O3
SKU: SIH-485 Categories: ,

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SIH-485_WHI-P131_Chemical_Structure.png
Product Name WHI P131
Description

JAK3 kinase inhibitor

Purity >98%
CAS No. 202475-60-3
Molecular Formula C16H15N3O3
Molecular Weight 297.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml)
Source Synthetic
Appearance White to off-white solid
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
InChI InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChIKey HOZUXBLMYUPGPZ-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product WHI P131 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-485)

Biological Description

Alternative Names WHI-P131, Janex 1, 4-​[(6,​7-​dimethoxy-​4-​quinazolinyl)amino]-​phenol
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 3794
Scientific Background WHI P131, also known as Janex-1, is a potent, reversible, and selective inhibitor of Janus kinase 3 (JAK3). In neuroscience, WHI P131 is used to investigate the role of JAK3 signaling in neuroinflammation and glioblastoma progression. It has been shown to inhibit glioblastoma cell adhesion and migration, as well as thrombin-induced platelet aggregation. Given the involvement of JAK/STAT pathways in neuroimmune responses, WHI P131 is a valuable tool for studying neuroinflammatory mechanisms and potential therapeutic interventions in neurodegenerative diseases.
References 1. Sudbeck E.A., et al. (1999) Clin. Cancer Res: J. Am. Asso. Cancer Res. 5(6): 1569–1582.

Product Images

<p>Chemical structure of WHI P131 (SIH-485), a JAK3 kinase inhibitor. CAS #: 202475-60-3. Molecular Formula: C16H15N3O3. Molecular Weight: 297.3 g/mol.</p>

Chemical structure of WHI P131 (SIH-485), a JAK3 kinase inhibitor. CAS #: 202475-60-3. Molecular Formula: C16H15N3O3. Molecular Weight: 297.3 g/mol.

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