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| Product Name | WHI P131 |
| Description |
JAK3 kinase inhibitor |
| Purity | >98% |
| CAS No. | 202475-60-3 |
| Molecular Formula | C16H15N3O3 |
| Molecular Weight | 297.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC |
| InChI | InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19) |
| InChIKey | HOZUXBLMYUPGPZ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | WHI P131 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-485) |
Biological Description
| Alternative Names | WHI-P131, Janex 1, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 3794 |
| Scientific Background | WHI P131, also known as Janex-1, is a potent, reversible, and selective inhibitor of Janus kinase 3 (JAK3). In neuroscience, WHI P131 is used to investigate the role of JAK3 signaling in neuroinflammation and glioblastoma progression. It has been shown to inhibit glioblastoma cell adhesion and migration, as well as thrombin-induced platelet aggregation. Given the involvement of JAK/STAT pathways in neuroimmune responses, WHI P131 is a valuable tool for studying neuroinflammatory mechanisms and potential therapeutic interventions in neurodegenerative diseases. |
| References | 1. Sudbeck E.A., et al. (1999) Clin. Cancer Res: J. Am. Asso. Cancer Res. 5(6): 1569–1582. |
Product Images
Chemical structure of WHI P131 (SIH-485), a JAK3 kinase inhibitor. CAS #: 202475-60-3. Molecular Formula: C16H15N3O3. Molecular Weight: 297.3 g/mol.
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