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| Product Name | WP1130 |
| Description |
Deubiquitinase (DUB) Inhibitor |
| Purity | >98% |
| CAS No. | 856243-80-6 |
| Molecular Formula | C19H18BrN3O |
| Molecular Weight | 384.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 45 mg/ml DMSO, 25 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | Pale Yellow Solid |
| SMILES | CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N |
| InChI | InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1 |
| InChIKey | LIDOPKHSVQTSJY-VMEIHUARSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | WP-1130 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-337) |
Biological Description
| Alternative Names | (2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 11222830 |
| Scientific Background | WP1130 is a novel deubiquitinase (DUB) inhibitor that targets USP9x, USP5, USP14, and UCH37, leading to accumulation of polyubiquitinated proteins. It blocks Jak2 signaling and is used in neuroscience to investigate the regulation of protein degradation, stress signaling, and neurodegenerative disease pathways involving ubiquitin-proteasome system dysfunction. |
| References |
1. KapuriaV., et al. (2010) Cancer Res. 70: 9265. 2. Kapuria V., et al. (2011) Cell Signal. 23: 2076. |
Product Images
Chemical structure of WP-1130 (SIH-337), a DUB inhibitor. CAS #: 856243-80-6. Molecular Formula: C19H18BrN3O. Molecular Weight: 384.3 g/mol.
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