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| Product Name | WP-1130 |
| Description |
DUB inhibitor |
| Purity | >98% |
| CAS No. | 856243-80-6 |
| Molecular Formula | C19H18BrN3O |
| Molecular Weight | 384.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 45 mg/ml DMSO, 25 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | Pale Yellow Solid |
| SMILES | CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N |
| InChI | InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1 |
| InChIKey | LIDOPKHSVQTSJY-VMEIHUARSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | WP-1130 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-337) |
Biological Description
| Alternative Names | (2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 11222830 |
| Scientific Background | A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Blocks Jak2 signaling via Jak2 ubiquitination. |
| References |
1. KapuriaV., et al. (2010) Cancer Res. 70: 9265. 2. Kapuria V., et al. (2011) Cell Signal. 23: 2076. |
Product Images
Chemical structure of WP-1130 (SIH-337), a DUB inhibitor. CAS #: 856243-80-6. Molecular Formula: C19H18BrN3O. Molecular Weight: 384.3 g/mol.
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