Zafirlukast

Hsp70 inhibitor

Catalog No. SIH-361

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CAS No. 107753-78-6
Molecular Formula C31H33N3O6S
SKU: SIH-361 Categories: ,

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SIH-361_Zafirlukast_Chemical_Structure.png
Product Name Zafirlukast
Description

Hsp70 inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 107753-78-6
Molecular Formula C31H33N3O6S
Molecular Weight 575.7
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO
Source Synthetic
Appearance White to Pink Solid
SMILES CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(C=C2)CC3=CN(C4=C3C=C(C=C4)NC(=O)OC5CCCC5)C)OC
InChI InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32
InChIKey YEEZWCHGZNKEEK-UHFFFAOYSA-N
Safety Phrases Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product Zafirlukast (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-361)

Biological Description

Alternative Names Cyclopentyl [3-(2-methoxy-4-{[(2-methylphenyl)sulfonyl]carbamoyl}benzyl)-1-methyl-1H-indol-5-yl]carbamate; ICI-204219
Research Areas Cancer, Heat Shock
PubChem ID 5717148
Scientific Background Zafirlukast, a leukotriene receptor antagonist and HSP70 inhibitor (IC50 = 37 µM), is primarily known for asthma treatment but is gaining interest in neurodegenerative disease research. HSP70 is a molecular chaperone essential for protein homeostasis and stress response—processes disrupted in Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Zafirlukast’s ability to modulate HSP70 activity and cross the blood-brain barrier makes it a promising candidate for targeting proteostasis and neuroinflammation. Its dual role in immunology and neurobiology underscores its potential for repurposing in neuroprotective strategies.
References 1. Miyata Y., et al. (2010) J. Biomol. 15: 1211.

Product Images

<p>Chemical structure of Zafirlukast (SIH-361), a Hsp70 inhibitor. CAS #: 107753-78-6. Molecular Formula: C31H33N3O6S . Molecular Weight: 575.7 g/mol.</p>

Chemical structure of Zafirlukast (SIH-361), a Hsp70 inhibitor. CAS #: 107753-78-6. Molecular Formula: C31H33N3O6S . Molecular Weight: 575.7 g/mol.

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