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| Product Name | Zerumbone |
| Description |
NF-κB kinase inhibitor |
| Purity | >98% |
| CAS No. | 471-05-6 |
| Molecular Formula | C15H22O |
| Molecular Weight | 218.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (≥10 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | C/C/1=CCC(/C=C/C(=O)/C(=C/CC1)/C)(C)C |
| InChI | InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+ |
| InChIKey | GIHNTRQPEMKFKO-SKTNYSRSSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Zerumbone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-265) |
Biological Description
| Alternative Names | (2E,6E,10E)-2,6,9,9-Tetramethyl-2,6,10-cycloundecatrien-1-one |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5470187 |
| Scientific Background | Zerumbone is a natural sesquiterpene ketone isolated from Zingiber species, known for its anti-inflammatory and anticancer properties. In neuroscience, zerumbone has been investigated for its ability to potentiate TRAIL-induced apoptosis via upregulation of death receptors DR4 and DR5. Its selective cytotoxicity toward abnormal cells and ability to modulate apoptotic pathways make it a compound of interest in neuro-oncology and neurodegenerative disease research. |
| References | 1. Leu J.L., et al. (2009) Mol Cell. 36:15. |
Product Images
Chemical structure of Zerumbone (SIH-265), a Enhances apoptotic effect of TRAIL. CAS #: 471-05-6. Molecular Formula: C15H22O. Molecular Weight: 218.3 g/mol.
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