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| Product Name | ZM447439 |
| Description |
Aurora B kinase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 331771-20-1 |
| Molecular Formula | C29H31N5O4 |
| Molecular Weight | 513.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50mg/mL) |
| Source | Synthetic |
| Appearance | Orange solid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5 |
| InChI | InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32) |
| InChIKey | OGNYUTNQZVRGMN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | ZM447439 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-489) |
Biological Description
| Alternative Names | ZM 447439, N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 9914412 |
| Scientific Background | ZM447439 is a potent and selective inhibitor of Aurora B kinase, a key regulator of mitosis. In neuroscience, ZM447439 is used to study cell cycle regulation in neural progenitor cells and the role of mitotic kinases in neurodevelopment and neurodegeneration. By inducing mitotic arrest and apoptosis, it provides insights into the mechanisms of neuronal cell cycle re-entry and its contribution to neurodegenerative diseases such as Alzheimer’s. |
| References |
1. Walsby E., Walsh V., Pepper C., Burnett A., & Mills K. (2008) Haematologica. 93(5): 662–669. 2. Kim K.W., et al. (2007) Int. J. Rad.Oncol. Biol. Phy. 67(5): 1519–1525. |
Product Images
Chemical structure of ZM447439 (SIH-489), a Aurora B kinase inhibitor. CAS #: 331771-20-1. Molecular Formula: C29H31N5O4. Molecular Weight: 513.6 g/mol.
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