ZM447439

Aurora B kinase inhibitor

Catalog No. SIH-489

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CAS No. 331771-20-1
Molecular Formula C29H31N5O4
SKU: SIH-489 Categories: ,

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SIH-489_ZM-447439_Chemical_Structure.png
Product Name ZM447439
Description

Aurora B kinase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 331771-20-1
Molecular Formula C29H31N5O4
Molecular Weight 513.6
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (50mg/mL)
Source Synthetic
Appearance Orange solid
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5
InChI InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
InChIKey OGNYUTNQZVRGMN-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product ZM447439 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-489)

Biological Description

Alternative Names ZM 447439, N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 9914412
Scientific Background ZM447439 is a potent and selective inhibitor of Aurora B kinase, a key regulator of mitosis. In neuroscience, ZM447439 is used to study cell cycle regulation in neural progenitor cells and the role of mitotic kinases in neurodevelopment and neurodegeneration. By inducing mitotic arrest and apoptosis, it provides insights into the mechanisms of neuronal cell cycle re-entry and its contribution to neurodegenerative diseases such as Alzheimer’s.
References 1. Walsby E., Walsh V., Pepper C., Burnett A., & Mills K. (2008) Haematologica. 93(5): 662–669.
2. Kim K.W., et al. (2007) Int. J. Rad.Oncol. Biol. Phy. 67(5): 1519–1525.

Product Images

<p>Chemical structure of ZM447439 (SIH-489), a Aurora B kinase inhibitor. CAS #: 331771-20-1. Molecular Formula: C29H31N5O4. Molecular Weight: 513.6 g/mol.</p>

Chemical structure of ZM447439 (SIH-489), a Aurora B kinase inhibitor. CAS #: 331771-20-1. Molecular Formula: C29H31N5O4. Molecular Weight: 513.6 g/mol.

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