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| Product Name | JC-1 |
| Description |
Mitochondrial membrane potential dependent fluorescent dye |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 3520-43-2 |
| Molecular Formula | C25H27Cl4IN4 |
| Molecular Weight | 652.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Membrane Potential Probe |
| Solubility | May be dissolved in DMSO (20 mg/ml) |
| Source | Synthetic |
| Appearance | Red powder |
| SMILES | CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-] |
| InChI | InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1 |
| InChIKey | FYNNIUVBDKICAX-UHFFFAOYSA-M |
| Safety Phrases |
This product does not require a Material Safety Data Sheet under the Occupational Safety and Health Administration standard entitled "Hazard Communication" 29 CFR 1910.1200 for the United States. The product does not meet the criteria of W.H.M.I.S. classification as a controlled product. As a result, a W.H.M.I.S. Material Safety Data Sheet is not required (in Canada) for this product. |
| Cite This Product | JC-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-562) |
Biological Description
| Alternative Names | 5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide, , 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole;iodide, Jc-1; 3520-43-2; JC-1 jodide; JC1 dye; CBIC2(3); 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide |
| Research Areas | Apoptosis, Cancer, Cell Cycle, Fluorescent Proteins, Mitochondrial, Tags and Cell Markers |
| PubChem ID | 5492929 |
| Scientific Background | JC-1 is a fluorescent dye that is able to pass across the mitochondrial membrane. It is used to measure mitochondrial membrane potential. At low membrane potentials, it remains a monomer and emits green-fluorescent light (λex=485 nm, λem=520 nm). At higher membrane potentials, it forms "J-aggregates", which emit red-fluorescent light (λex=520-570 nm, λem=570-610 nm). The ratio of red/green fluorescence is based only on the membrane potential, and not on mitochondrial size, shape or density. |
Product Images
Chemical structure of JC-1 (SIH-562), a Mitochondrial membrane potential dependent fluorescent dye. CAS #: 3520-43-2. Molecular Formula: C25H27Cl4IN4. Molecular Weight: 652.2 g/mol.
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