KT5720

Name: KT5720
SKU: SIH-457
Availability: InStock

PKA kinase inhibitor

Catalog No. SIH-457

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CAS No.	108068-98-0
Molecular Formula	C32H31N3O5

SKU: SIH-457 Categories: Inhibitor, Small Molecules

Product Name	KT5720
Description	PKA kinase inhibitor
Purity	>98% (TLC)
CAS No.	108068-98-0
Molecular Formula	C₃₂H₃₁N₃O₅
Molecular Weight	537.6
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in methanol: clear colorless solution at 5 mg/ml
Source	Synthetic
Appearance	White powder
SMILES	[N]47C1=C(C6=C(C2=C1[N](C3=CC=CC=C23)[C@H]5O[C@@]4([C@](C5)(O)C(=O)OCCCCCC)C)C(NC6)=O)C8=C7C=CC=C8
InChI	InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,3
InChIKey	ZHEHVZXPFVXKEY-UHFFFAOYSA-N
Safety Phrases	Classification: Specific target organ toxicity-single exposure (Category 1), H370 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H370 Causes damage to organs. Precautionary statements: P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant
Cite This Product	KT5720 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-457)

Alternative Names	(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	3844
Scientific Background	KT5720 is a potent and selective inhibitor of protein kinase A (PKA). This compound blocks PKA signaling through competitive inhibition. It causes no significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (mlCK). KT5720 has been shown to reversibly arrests human skin fibroblasts in the G1 phase. It is cell permeable.
References	1. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440. 2. Gadbois D.M., Crissman H.A., Tobey R.A., & Bradbury E.M. (1992) Pro. Na. Aca. Sci. USA. 89(18): 8626–8630.

Chemical structure of KT5720 (SIH-457), a PKA kinase inhibitor. CAS #: 108068-98-0. Molecular Formula: C32H31N3O5. Molecular Weight: 537.6 g/mol.

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