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| Product Name | Lactacystin |
| Description |
Proteasome inhibitor |
| Purity | >98% |
| CAS No. | 133343-34-7 |
| Molecular Formula | C15H24N2O7S |
| Molecular Weight | 376.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO, Water or Ethanol |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C[C@@H]1[C@@H](C(NC1=O)([C@H](C(C)C)O)C(=O)SC[C@@H](C(=O)O)NC(=O)C)O |
| InChI | InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1 |
| InChIKey | DAQAKHDKYAWHCG-RWTHQLGUSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Lactacystin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-327) |
Biological Description
| Alternative Names | (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors |
| PubChem ID | 6610292 |
| Scientific Background | Lactacystin is a specific proteasome inhibitor that targets multiple proteolytic activities, with the strongest inhibition observed for chymotrypsin-like activity, followed by trypsin-like activity. Its ability to modulate proteasome function makes it a valuable tool in neuroscience research, particularly in studies of protein degradation, synaptic plasticity, and neurodegenerative disease models where proteostasis is disrupted. |
| References |
1. Omura S., et al. (1991) J. Antibiot. 44: 113. 2. Fenteany G., et al. (1995) Science 268: 726 |
Product Images
Chemical structure of Lactacystin (SIH-327), a Proteasome inhibitor. CAS #: 133343-34-7. Molecular Formula: C15H24N2O7S. Molecular Weight: 376.4 g/mol.
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