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| Product Name | Lapatinib |
| Description |
EGFR, HER2 inhibitor |
| Purity | >99% |
| CAS No. | 231277-92-2 |
| Molecular Formula | C29H26ClFN4O4S |
| Molecular Weight | 581.1 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Solubility in water is 0.007 mg/ml and in 0.1N HCl is 0.001 mg/ml at 25° C |
| Source | Synthetic |
| Appearance | Yellow crystalline solid |
| SMILES | C2=C1C(=NC=NC1=CC=C2C3=CC=C(O3)CNCC[S](=O)(=O)C)NC4=CC=C(C(=C4)Cl)OCC5=CC=CC(=C5)F |
| InChI | InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35 |
| InChIKey | BCFGMOOMADDAQU-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Lapatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-459) |
Biological Description
| Alternative Names | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Growth Factor Receptor Inhibitors |
| PubChem ID | 208908 |
| Scientific Background | Lapatinib is a tyrosine kinase inhibitor. Specifically, it interrupts the ErbB/neu and epidermal growth factor receptor (EGFR) pathways. It is an antineoplastic agent used in breast cancer research. In solid tumor cells, Lapatinib binds to the ATP-binding pocket of the protein kinase domains on EGFR/ErbB, preventing self-phosphorylation. |
| References |
1. Chien A.J., et al. (2014) J. Clin. Oncol: J. Am. Clin. Oncol. 32(14): 1472–1479. 2. Dahal B.K., et al. (2010) Am. J. Resp. Critical Care Med. 181(2): 158–167. |
Product Images
Chemical structure of Lapatinib (SIH-459), a EGFR and HER2 inhibitor. CAS #: 231277-92-2. Molecular Formula: C29H26ClFN4O4S. Molecular Weight: 581.1 g/mol.
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