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| Product Name | LH 846 |
| Description |
Casein kinase 1d inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 639052-78-1 |
| Molecular Formula | C16H13ClN2OS |
| Molecular Weight | 316.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White to beige powder |
| SMILES | CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3 |
| InChI | InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20) |
| InChIKey | DYHAMRNAHTWYKY-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4) Chronic aquatic toxicity(Category 4) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H413 May cause long lasting harmful effects to aquatic life. |
| Cite This Product | LH 846 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-503) |
Biological Description
| Alternative Names | LH846, LH-846, N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide |
| Research Areas | Cell Signaling |
| PubChem ID | 851474 |
| Scientific Background | LH 846 is a selective inhibitor of Casein Kinase 1 delta (CK1δ), a key regulator of circadian rhythm and PER1 protein stability. CK1δ has been implicated in neurodegenerative diseases such as Alzheimer’s, where circadian disruption and abnormal protein phosphorylation are common. By modulating CK1δ activity, LH 846 offers a valuable tool for exploring the links between circadian regulation, neurodegeneration, and cognitive decline. |
| References | 1. Lee J.W., et al. (2011) Angewandte Chemie. 50(45): 10608–10611. |
Product Images
Chemical structure of LH 846 (SIH-503), a Casein kinase 1d inhibitor. CAS #: 639052-78-1. Molecular Formula: C16H13ClN2OS. Molecular Weight: 316.8 g/mol.
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