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| Product Name | 24(S)-Hydroxycholesterol |
| Description |
LXR ligand |
| Purity | >98% |
| CAS No. | 474-73-7 |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Ligand |
| Solubility | Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C). |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | [C@]24([C@H]([C@@H]1CC=C3[C@@]([C@H]1CC2)(CC[C@H](O)C3)C)CC[C@@H]4[C@@H](CC[C@@H](C(C)C)O)C)C |
| InChI | InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1 |
| InChIKey | IOWMKBFJCNLRTC-XWXSNNQWSA-N |
| Safety Phrases |
Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes |
| Cite This Product | 24(S)-Hydroxycholesterol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-384) |
Biological Description
| Alternative Names | (3β,24S)-Cholest-5-ene-3,24-diol |
| Research Areas | Cell Signaling |
| PubChem ID | 121948 |
| Scientific Background | 24(S)-Hydroxycholesterol is a brain-derived oxysterol and a potent endogenous agonist of liver X receptors (LXRs), which regulate cholesterol homeostasis and inflammatory gene expression in the central nervous system. As a major cholesterol metabolite in the brain, it plays a critical role in maintaining neuronal lipid balance. Elevated levels of 24(S)-hydroxycholesterol in cerebrospinal fluid have been associated with early-stage Alzheimer’s disease and mild cognitive impairment, making it a valuable biomarker for neurodegeneration. Additionally, its neurotoxic effects on neuronal cells underscore its dual role as both a physiological regulator and a potential contributor to disease pathology. |
| References |
1. Chawla A., et al. (2001) Science. 294(5548): 1866-70. 2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804. 3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5. 4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5. 5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7. |
Product Images
Chemical structure of 24(S)-Hydroxycholesterol (SIH-384), a LXR ligand. CAS #: 474-73-7. Molecular Formula: C27H46O2 . Molecular Weight: 402.7 g/mol.
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