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| Product Name | JC-1 |
| Description |
Mitochondrial membrane potential dependent fluorescent dye |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 3520-43-2 |
| Molecular Formula | C25H27Cl4IN4 |
| Molecular Weight | 652.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Membrane Potential Probe |
| Solubility | May be dissolved in DMSO (20 mg/ml) |
| Source | Synthetic |
| Appearance | Red powder |
| SMILES | CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-] |
| InChI | InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1 |
| InChIKey | FYNNIUVBDKICAX-UHFFFAOYSA-M |
| Safety Phrases |
This product does not require a Material Safety Data Sheet under the Occupational Safety and Health Administration standard entitled "Hazard Communication" 29 CFR 1910.1200 for the United States. The product does not meet the criteria of W.H.M.I.S. classification as a controlled product. As a result, a W.H.M.I.S. Material Safety Data Sheet is not required (in Canada) for this product. |
| Cite This Product | JC-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-562) |
Biological Description
| Alternative Names | 5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide, , 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole;iodide, Jc-1; 3520-43-2; JC-1 jodide; JC1 dye; CBIC2(3); 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide |
| Research Areas | Apoptosis, Cancer, Cell Cycle, Fluorescent Proteins, Mitochondrial, Tags and Cell Markers |
| PubChem ID | 5492929 |
| Scientific Background | JC-1 is a cationic dye used to assess mitochondrial membrane potential, a key indicator of mitochondrial health and function. In neuroscience, JC-1 is widely employed to study mitochondrial dysfunction, which is a hallmark of neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. JC-1 accumulates in mitochondria and exhibits potential-dependent fluorescence shifts, enabling real-time monitoring of mitochondrial depolarization and apoptosis. Its application in neuronal models helps elucidate the role of mitochondrial dynamics in cell survival, oxidative stress, and energy metabolism, contributing to the understanding of neurodegenerative mechanisms. |
Product Images
Chemical structure of JC-1 (SIH-562), a Mitochondrial membrane potential dependent fluorescent dye. CAS #: 3520-43-2. Molecular Formula: C25H27Cl4IN4. Molecular Weight: 652.2 g/mol.
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