JC-1

Mitochondrial membrane potential dependent fluorescent dye

Catalog No. SIH-562

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CAS No. 3520-43-2
Molecular Formula C25H27Cl4IN4
SKU: SIH-562 Categories: ,

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SIH-562-JC-1-Chemical-Structure.png
Product Name JC-1
Description

Mitochondrial membrane potential dependent fluorescent dye

Purity >98% (HPLC); NMR (conforms)
CAS No. 3520-43-2
Molecular Formula C25H27Cl4IN4
Molecular Weight 652.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Membrane Potential Probe
Solubility May be dissolved in DMSO (20 mg/ml)
Source Synthetic
Appearance Red powder
SMILES CCN1C2=CC(=C(C=C2[N+](=C1C=CC=C3N(C4=CC(=C(C=C4N3CC)Cl)Cl)CC)CC)Cl)Cl.[I-]
InChI InChI=1S/C25H27Cl4N4.HI/c1-5-30-20-12-16(26)17(27)13-21(20)31(6-2)24(30)10-9-11-25-32(7-3)22-14-18(28)19(29)15-23(22)33(25)8-4;/h9-15H,5-8H2,1-4H3;1H/q+1;/p-1
InChIKey FYNNIUVBDKICAX-UHFFFAOYSA-M
Safety Phrases This product does not require a Material Safety Data Sheet under the Occupational Safety and Health Administration standard entitled "Hazard Communication" 29 CFR 1910.1200 for the United States.
The product does not meet the criteria of W.H.M.I.S. classification as a controlled product. As a result, a W.H.M.I.S. Material Safety Data Sheet is not required (in Canada) for this product.
Cite This Product JC-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-562)

Biological Description

Alternative Names 5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide, , 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole;iodide, Jc-1; 3520-43-2; JC-1 jodide; JC1 dye; CBIC2(3); 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide
Research Areas Apoptosis, Cancer, Cell Cycle, Fluorescent Proteins, Mitochondrial, Tags and Cell Markers
PubChem ID 5492929
Scientific Background JC-1 is a cationic dye used to assess mitochondrial membrane potential, a key indicator of mitochondrial health and function. In neuroscience, JC-1 is widely employed to study mitochondrial dysfunction, which is a hallmark of neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. JC-1 accumulates in mitochondria and exhibits potential-dependent fluorescence shifts, enabling real-time monitoring of mitochondrial depolarization and apoptosis. Its application in neuronal models helps elucidate the role of mitochondrial dynamics in cell survival, oxidative stress, and energy metabolism, contributing to the understanding of neurodegenerative mechanisms.

Product Images

<p>Chemical structure of JC-1 (SIH-562), a Mitochondrial membrane potential dependent fluorescent dye. CAS #: 3520-43-2. Molecular Formula: C25H27Cl4IN4. Molecular Weight: 652.2 g/mol.</p>

Chemical structure of JC-1 (SIH-562), a Mitochondrial membrane potential dependent fluorescent dye. CAS #: 3520-43-2. Molecular Formula: C25H27Cl4IN4. Molecular Weight: 652.2 g/mol.

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