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| Product Name | Nitrendipine |
| Description |
L-type Ca channel blocker |
| Purity | >98% (TLC) |
| CAS No. | 39562-70-4 |
| Molecular Formula | C18H20N2O6 |
| Molecular Weight | 360.37 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (20mg/mL); or ethanol (10mg/mL) |
| Source | Synthetic |
| Appearance | Yellow Crystalline Solid |
| SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C |
| InChI | InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3 |
| InChIKey | PVHUJELLJLJGLN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not fully tested yet. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with shin and eyes Risk Phrases: R62 - Possible risk of impaired fertility Hazard Phrases: H312-H332 Precautionary Phrases: P280 |
| Cite This Product | Nitrendipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-320) |
Biological Description
| Alternative Names | Ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| PubChem ID | 11931106 |
| Scientific Background | Nitrendipine is a dihydropyridine calcium channel blocker that targets L-type calcium channels in smooth muscle and neurons. By reducing calcium influx, it may help mitigate excitotoxicity—a key factor in neurodegeneration. Its neuroprotective potential is being explored in models of stroke and neurodegenerative diseases where calcium overload contributes to cell death. |
| References | 1. Peterson B.Z., Tanada T.N., Catterall W.A. (1996) J Biol Chem. 271: 5293-5296. |
Product Images
Chemical structure of Nitrendipine (SIH-320), a L-type Ca channel blocker. CAS #: 39562-70-4. Molecular Formula: C18H20N2O6. Molecular Weight: 360.37 g/mol.
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