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| Product Name | Okadaic acid |
| Description |
PP1 and PP2A inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 78111-17-8 |
| Molecular Formula | C44H68O13 |
| Molecular Weight | 805.0 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in chloroform, ethanol, methanol, acetone or ethyl acetate |
| Source | Synthetic |
| Appearance | White crystalline solid |
| SMILES | [C@@]45(OC3[C@H](O[C@H]([C@@H](O)C[C@@H](C2O[C@]1(OCCCC1)CC[C@H]2C)C)C([C@H]3O)=C)CC4)O[C@H](CC5)C=C[C@H]([C@H]7O[C@]6(O[C@@H](CC[C@H]6O)C[C@](O)(C)C(O)=O)C=C(C7)C)C |
| InChI | InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51 |
| InChIKey | QNDVLZJODHBUFM-WFXQOWMNSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H315 Causes skin irritation Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P361 Remove/Take off immediately all contaminated clothing. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | Okadaic acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-521) |
Biological Description
| Alternative Names | 9,10-Deepithio-9,10-didehydroacanthifolicin |
| Research Areas | Cell Signaling |
| PubChem ID | 446512 |
| Scientific Background | Okadaic acid is a potent and selective inhibitor of protein phosphatases PP1 and PP2A, enzymes critical to cellular signaling and homeostasis. Widely used in neuroscience research, Okadaic acid induces tau hyperphosphorylation and neurofibrillary tangle formation, mimicking key features of Alzheimer's disease pathology. As such, it serves as a valuable tool for modeling neurodegeneration and studying the molecular mechanisms underlying tauopathies and other neurodegenerative disorders. |
| References | 1. Cohen P., Holmes C.F., & Tsukitani Y. (1990) Trends Biochem. 15(3): 98–102. |
Product Images
Chemical structure of Okadaic acid (SIH-521), a PP1 and PP2A inhibitor. CAS #: 78111-17-8. Molecular Formula: C44H68O13. Molecular Weight: 805 g/mol.
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