Pinacidil Monohydrate

K+ channel activator

Catalog No. SIH-563

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CAS No. 85371-64-8
Molecular Formula C13H19N5 · H2O
SKU: SIH-563 Categories: ,

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SIH-563-Pinacidil-Monohydrate-Chemical-Structure.png
Product Name Pinacidil Monohydrate
Description

K+ channel activator

Purity >98% (HPLC); NMR (conforms)
CAS No. 85371-64-8
Molecular Formula C13H19N5 · H2O
Molecular Weight 263.34
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Activator
Solubility May be dissolved in DMSO (25 mg/ml, warm); or ethanol (25 mg/ml, warm)
Source Synthetic
Appearance White powder
SMILES CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1.O
InChI InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
InChIKey AFJCNBBHEVLGCZ-UHFFFAOYSA-N
Safety Phrases WHMIS Classification:
D2B Toxic Material Causing Other Toxic Effects: Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant

GHS Classification:
Acute toxicity, Oral (Category 4)
Skin irritation (Category 2)
Eye irritation (Category 2A)
Specific target organ toxicity - single exposure (Category 3), Respiratory system

GHS Label elements, including precautionary statements
Signal word: Warning

Hazard statement(s):
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statement(s):
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product Pinacidil Monohydrate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-563)

Biological Description

Alternative Names (±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate, PINACIDIL MONOHYDRATE; Pindac; Pinacidil hydrate; 85371-64-8; Pinacidil anhydrous; CHEBI:34923, Pindac
Research Areas Apoptosis, Cancer, Ion Channels, Neurodegeneration, Neuroscience, Neurotransmission, Oxidative Stress, Parkinson's Disease, Potassium Channels
PubChem ID 55329
Scientific Background Pinacidil Monohydrate is a potassium channel opener that activates ATP-sensitive K⁺ (K_ATP) channels, leading to membrane hyperpolarization and reduced cellular excitability. In neuroscience, Pinacidil is used to study neurovascular coupling, mitochondrial function, and neuroprotection. Its ability to modulate ion channel activity and reduce calcium influx makes it relevant in models of ischemia, epilepsy, and neurodegeneration. Pinacidil is also investigated for its role in preserving mitochondrial integrity and reducing oxidative stress in neurons.

Product Images

<p>Chemical structure of Pinacidil Monohydrate (SIH-563), a K+ channel activator. CAS #: 85371-64-8. Molecular Formula: C13H19N5 · H2O. Molecular Weight: 263.34 g/mol.</p>

Chemical structure of Pinacidil Monohydrate (SIH-563), a K+ channel activator. CAS #: 85371-64-8. Molecular Formula: C13H19N5 · H2O. Molecular Weight: 263.34 g/mol.

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