Product Name | Pinacidil Monohydrate |
Description |
K+ channel activator |
Purity | >98% (HPLC); NMR (conforms) |
CAS No. | 85371-64-8 |
Molecular Formula | C13H19N5 · H2O |
Molecular Weight | 263.34 |
Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Storage Temperature | -20ºC |
Shipping Temperature | Shipped Ambient |
Product Type | Activator |
Solubility | May be dissolved in DMSO (25 mg/ml, warm); or ethanol (25 mg/ml, warm) |
Source | Synthetic |
Appearance | White powder |
SMILES | CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1.O |
InChI | InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2 |
InChIKey | AFJCNBBHEVLGCZ-UHFFFAOYSA-N |
Safety Phrases |
WHMIS Classification: D2B Toxic Material Causing Other Toxic Effects: Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant GHS Classification: Acute toxicity, Oral (Category 4) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3), Respiratory system GHS Label elements, including precautionary statements Signal word: Warning Hazard statement(s): H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Cite This Product | Pinacidil Monohydrate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-563) |
Alternative Names | (±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate, PINACIDIL MONOHYDRATE; Pindac; Pinacidil hydrate; 85371-64-8; Pinacidil anhydrous; CHEBI:34923, Pindac |
Research Areas | Apoptosis, Cancer, Ion Channels, Neurodegeneration, Neuroscience, Neurotransmission, Oxidative Stress, Parkinson's Disease, Potassium Channels |
PubChem ID | 55329 |
Scientific Background | Pinacidil Monohydrate is a potassium channel opener that activates ATP-sensitive K⁺ (K_ATP) channels, leading to membrane hyperpolarization and reduced cellular excitability. In neuroscience, Pinacidil is used to study neurovascular coupling, mitochondrial function, and neuroprotection. Its ability to modulate ion channel activity and reduce calcium influx makes it relevant in models of ischemia, epilepsy, and neurodegeneration. Pinacidil is also investigated for its role in preserving mitochondrial integrity and reducing oxidative stress in neurons. |
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