PMA

Name: PMA
SKU: SIH-508
Availability: InStock

Protein Kinase C Activator

Catalog No. SIH-508

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CAS No.	16561-29-8
Molecular Formula	C36H58O8

SKU: SIH-508 Categories: Activator, Small Molecules

Product Name	PMA
Description	Protein Kinase C Activator
Purity	99% (TLC)
CAS No.	16561-29-8
Molecular Formula	C₃₆H₅₈O₈
Molecular Weight	616.8
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Activator
Solubility	Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers
Source	Synthetic
Appearance	Colorless amorphous film or foam
SMILES	O=C(OC41C(C2/C=C(/CO)CC3(O)C(O)C(=C/C3C2(O)C(C)C1OC(=O)CCCCCCCCCCCCC)C)C4(C)C)C
InChI	InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,
InChIKey	PHEDXBVPIONUQT-RGYGYFBISA-N
Safety Phrases	Classification: Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. Precautionary statements: P264 Wash skin thoroughly after handling. P280 Wear protective gloves. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse.
Cite This Product	PMA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-508)

Alternative Names	Phorbol 12-myristate 13-acetate
Research Areas	Cell Signaling
PubChem ID	27924
Scientific Background	PMA is a potent phorbol ester widely used as a reversible activator of protein kinase C (PKC). In neuroscience, PMA serves as a critical tool for studying synaptic plasticity, signal transduction, and neuroinflammation. By mimicking diacylglycerol, PMA activates PKC isoforms, influencing neuronal gene expression, neurotransmitter release, and long-term potentiation. Its ability to modulate neuroinflammatory pathways and glial activation makes it relevant in models of neurodegenerative diseases such as Alzheimer's and Parkinson's. PMA is also used to investigate tumor-promoting mechanisms in neural tissues, offering insights into brain cancer biology.
References	1. Murphy T. V., Prountzos C., Kotsonis P., Iannazzo L., & Majewski H. (1999). Euro.J. Pharm. 381(1): 77–84. 2. Castagna M., et al. (1982) J. Biol. Chem. 257(13): 7847–7851.

Chemical structure of PMA (SIH-508), a PKC kinase activator. CAS #: 16561-29-8. Molecular Formula: C36H58O8. Molecular Weight: 616.8 g/mol.

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