Puromycin HCl

Translation inhibitor

Catalog No. SIH-248

5 out of 5 based on 1 customer rating
CAS No. 58-58-2
Molecular Formula C22H29N7O5•2HCl
SKU: SIH-248 Categories: ,

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SIH-248_Puromycin_HCl_Chemical_Structure.png
Product Name Puromycin HCl
Description

Translation inhibitor

Purity >98% (TLC, HPLC); NMR (Conforms)
CAS No. 58-58-2
Molecular Formula C22H29N7O52HCl
Molecular Weight 544.43
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml)
Source Synthetic
Appearance Off-white powder
SMILES CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O
InChI InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5
InChIKey RXWNCPJZOCPEPQ-WABMVTPESA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Puromycin HCl (StressMarq Biosciences, Canada, Cat # SIH-248)

Biological Description

Alternative Names 3'-Deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine
Research Areas Apoptosis, Cancer
PubChem ID 5891
Scientific Background Puromycin is an antibiotic that is a protein synthesis inhibitor that causes premature chain termination during translation taking place in the ribosome. Part of the molecule resembles the 3' end of the tRNA. It enters the A site and transfers to the growing chain, causing the premature release. It is not selective for either prokaryotes or eukaryotes.
References 1.  Azzam and Algranati. (1973) Proc Natl Acad Sci. 70: 3866.

Product Images

<p>Chemical structure of Puromycin HCl (SIH-248), a Translation inhibitor. CAS #: 58-58-2. Molecular Formula: C22H29N7O5 x 2HCl. Molecular Weight: 544.43 g/mol.</p>

Chemical structure of Puromycin HCl (SIH-248), a Translation inhibitor. CAS #: 58-58-2. Molecular Formula: C22H29N7O5 x 2HCl. Molecular Weight: 544.43 g/mol.

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