(R,S)-Niguldipine HCl

Ca2+ channel blocker

Catalog No. SIH-319

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CAS No. 119934-51-9
Molecular Formula C36H39N3O6•HCl
SKU: SIH-319 Categories: ,

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SIH-319_R-Niguldipine_HCl_Chemical_Structure.png
Product Name (R,S)-Niguldipine HCl
Description

Ca2+ channel blocker

Purity >98%
CAS No. 119934-51-9
Molecular Formula C36H39N3O6•HCl
Molecular Weight 646.18
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 10 mM in water
Source Synthetic
Appearance Yellow solid
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Cite This Product (R, S)-Niguldipine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-319)

Biological Description

Alternative Names (R,S)-1,4-Dihydro-2,6-dimethyl-4-(3-n­itrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Research Areas Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
Scientific Background Niguldipine is a calcium channel blocker and alpha1-adrenergic receptor antagonist. In neuroscience, its dual action on calcium influx and adrenergic signaling makes it a candidate for studying neurovascular coupling and synaptic transmission. Its modulation of intracellular calcium dynamics may have implications for neurodegenerative disease models involving calcium dysregulation.
References 1. Boer R., Grassegger A., Schudt C., Glossman H. (1999) Eur J Pharmacol. 172(2): 131-145.
2. Robinson J.P., Kendall D.A. (1990) Br J Pharmacol. 100(1): 3-4.

Product Images

<p>Chemical structure of (R, S)-Niguldipine HCl (SIH-319), a L-type Ca channel blocker. CAS #: 113317-61-6. Molecular Formula: C36H39N3O6.HCl. Molecular Weight: 646.18 g/mol.</p>

Chemical structure of (R, S)-Niguldipine HCl (SIH-319), a L-type Ca channel blocker. CAS #: 113317-61-6. Molecular Formula: C36H39N3O6.HCl. Molecular Weight: 646.18 g/mol.

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