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| Product Name | Roscovitine |
| Description |
p34/cdc2 inhibitor |
| Purity | >95% (HPLC, TLC) |
| CAS No. | 186692-46-6 |
| Molecular Formula | C19H26N6O |
| Molecular Weight | 354.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | [C@H](NC2=NC1=C(N=C[N]1C(C)C)C(=N2)NCC3=CC=CC=C3)(CO)CC |
| InChI | InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 |
| InChIKey | BTIHMVBBUGXLCJ-OAHLLOKOSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Roscovitine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-472) |
Biological Description
| Alternative Names | 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine |
| Research Areas | Cell Signaling |
| PubChem ID | 160355 |
| Scientific Background | Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating. |
| References | 1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526. |
Product Images
Chemical structure of Roscovitine (SIH-472), a p34/cdc2 inhibitor. CAS #: 186692-46-6. Molecular Formula: C19H26N6O. Molecular Weight: 354.4 g/mol.
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