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| Product Name | SC 514 |
| Description |
IKK-2 kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 354812-17-2 |
| Molecular Formula | C9H8N2OS2 |
| Molecular Weight | 224.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (>25 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C1=CSC=C1C2=CC(=C(S2)C(=O)N)N |
| InChI | InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12) |
| InChIKey | BMUACLADCKCNKZ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed Precautionary statements: P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician |
| Cite This Product | SC 514 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-475) |
Biological Description
| Alternative Names | 4-Amino-[2',3'-bithiophene]-5-carboxamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 2807869 |
| Scientific Background | SC 514 is a selective and reversible inhibitor of IκB kinase 2 / IKKβ (IKK-2). It has been shown to displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. SC-514 exhibits anti-inflammatory properties. SC 514 is cell permeable. |
| References |
1. Kishore N., et al. (2003) J. Biol. Chem. 278(35): 32861–32871. 2. Baxter A., et al. (2004) Bioorganic Med. Chem. Letters. 14(11): 2817–2822. |
Product Images
Chemical structure of SC 514 (SIH-475), a IKK-2 kinase inhibitor. CAS #: 354812-17-2. Molecular Formula: C9H8N2OS2. Molecular Weight: 224.3 g/mol.
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