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| Product Name | SC 79 |
| Description |
Akt kinase activator |
| Purity | 98% (TLC); NMR (Conforms) |
| CAS No. | 305834-79-1 |
| Molecular Formula | C17H17ClN2O5 |
| Molecular Weight | 364.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (100mg/mL); or ethanol (40mg/mL, warm) |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Cl)N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | SC 79 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-512) |
Biological Description
| Alternative Names | SC-79, SC79, 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester |
| Research Areas | Cell Signaling |
| Scientific Background | SC 79 is an activator of Akt (protein kinase B). Specifically, it has been shown to bind the plecktrin homology (PH) domain of Akt. This mimics the binding of Phosphatidylinositol (3,4,5)-trisphosphates, which induces a conformational change in Akt, that enhances phosphorylation and activation. |
| References | 1. Jo H., et al. (2012) Pro. Nat. Acad. Sci. USA. 109(26): 10581–10586. |
Product Images
Chemical structure of SC 79 (SIH-512), a Akt kinase activator. CAS #: 305834-79-1. Molecular Formula: C17H17ClN2O5. Molecular Weight: 364.8 g/mol.
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