Sirtinol

Name: Sirtinol
SKU: SIH-360
Availability: InStock

SIRT inhibitor

Catalog No. SIH-360

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CAS No.	410536-97-9
Molecular Formula	C26H22N2O2

SKU: SIH-360 Categories: Inhibitor, Small Molecules

Product Name	Sirtinol
Description	SIRT inhibitor
Purity	>98%
CAS No.	410536-97-9
Molecular Formula	C₂₆H₂₂N₂O₂
Molecular Weight	394.47
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in DMSO
Source	Synthetic
Appearance	Off-white to yellow crystals
SMILES	[C@@H](NC(=O)C1=CC=CC=C1NC=C/3C2=CC=CC=C2C=CC3=O)(C4=CC=CC=C4)C
InChI	InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,27H,1H3,(H,28,30)/b23-17-
InChIKey	YUGODMKHHCZZOI-QJOMJCCJSA-N
Safety Phrases	Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	Sirtinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-360)

Alternative Names	2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Research Areas	Cell Signaling
PubChem ID	5717148
Scientific Background	Cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 µM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
References	1. Grozinger CM., et al (2001) J.Biol.Chem. 276: 38837. 2. Mai A., et al (2005) J.Med.Chem. 48: 7789. 3. Kahyo T., et al (2008) J.Pharmacol.Sci. 108: 364. 4. Jung-Hynes B., et al (2009) J.Biol.Chem. 284: 3823.

Chemical structure of Sirtinol (SIH-360), a SIRT inhibitor. CAS #: 410536-97-9. Molecular Formula: C26H22N2O2. Molecular Weight: 394.47 g/mol.

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