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| Product Name | SRPIN340 |
| Description |
SR kinase inhibitor |
| Purity | >98% |
| CAS No. | 218156-96-8 |
| Molecular Formula | C18H18F3N3O |
| Molecular Weight | 349.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3 |
| InChI | InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25) |
| InChIKey | DWFGGOFPIISJIT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | SRPIN340 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-514) |
Biological Description
| Alternative Names | N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 2797577 |
| Scientific Background | SRPIN340 is a selective inhibitor of serine–arginine protein kinases (SRPKs), particularly SRPK1 and SRPK2. These kinases regulate alternative splicing of pre-mRNA, a process increasingly recognized in neurodegenerative disease mechanisms. SRPIN340 has been used to study the role of aberrant splicing in diseases such as ALS and frontotemporal dementia. Its ability to modulate splicing events makes it a promising tool for investigating RNA-based pathologies in the nervous system. |
| References | 1. Karakama Y., et al. (2010). Antimicrobial Agents Chemo. 54(8): 3179–3186. |
Product Images
Chemical structure of SRPIN340 (SIH-514), a SR kinase inhibitor. CAS #: 218156-96-8. Molecular Formula: C18H18F3N3O. Molecular Weight: 349.4 g/mol.
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Based on validation through cited publications.