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| Product Name | Sunitinib malate |
| Description |
VEGFR, PDGFR kinase inhibitor |
| Purity | >99% |
| CAS No. | 557795-19-4 |
| Molecular Formula | C22H27FN4O2 |
| Molecular Weight | 398.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (40 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C1=CC2=C(C=C1F)C(/C(N2)=O)=C/C3=C(C(=C([NH]3)C)C(NCCN(CC)CC)=O)C |
| InChI | InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- |
| InChIKey | WINHZLLDWRZWRT-ATVHPVEESA-N |
| Safety Phrases |
Classification: Reproductive toxicity (Category 1B), H360 Specific target organ toxicity-repeated exposure, Oral (Category 1), H372 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H360 May damage fertility or the unborn child. H372 Causes damage to organs through prolonged or repeated exposure if swallowed. Precautionary statements: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P281 Use personal protective equipment as required. P308 + P313 IF exposed or concerned: Get medical advice/ attention. P405 Store locked up. |
| Cite This Product | Sunitinib malate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-482) |
Biological Description
| Alternative Names | N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5329102 |
| Scientific Background | Sunitinib malate is a receptor tyrosine kinase inhibitor. It has been shown to target VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, c-KIT, FLT3, CSF-1R, Flk-1, and RET. |
| References | 1. Hersey P., et al. (2009) Annals of Oncology: ESMO. 20 Suppl 6: vi35–40. |
Product Images
Chemical structure of Sunitinib malate (SIH-482), a VEGFR, PDGFR kinase inhibitor. CAS #: 557795-19-4. Molecular Formula: C22H27FN4O2. Molecular Weight: 398.5 g/mol.
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