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| Product Name | Tolcapone |
| Description |
COMT inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 134308-13-7 |
| Molecular Formula | C14H11NO5 |
| Molecular Weight | 273.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml), or ethanol (25 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow powder |
| SMILES | Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+]([O-])=O |
| InChI | 1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3 |
| InChIKey | MIQPIUSUKVNLNT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled Hazard statement(s): H303 - May be harmful if swallowed. H400 - Very toxic to aquatic life. Precautionary statement(s) P273 Avoid release to the environment. |
| Cite This Product | Tolcapone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-540) |
Biological Description
| Alternative Names | (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone, Tolcapone, Tasmar, Ro 40-7592 |
| Research Areas | Neurodegeneration, Neuroscience, Parkinson's Disease |
| PubChem ID | 4659569 |
| Scientific Background | Tolcapone is a potent catechol-O-methyltransferase (COMT) inhibitor that enhances dopaminergic signaling by preventing dopamine degradation. It is clinically used in Parkinson’s disease and has demonstrated neuroprotective effects by inhibiting alpha-synuclein and beta-amyloid aggregation. Tolcapone also binds transthyretin (TTR), stabilizing it and preventing TTR-induced cytotoxicity. These multifaceted actions make Tolcapone a valuable compound in neurodegenerative disease research, particularly in Parkinson’s and Alzheimer’s disease models. |
Product Images
Chemical structure of Tolcapone (SIH-540), a COMT inhibitor. CAS #: 134308-13-7. Molecular Formula: C14H11NO5. Molecular Weight: 273.2 g/mol.
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