Discovery through Partnership | Excellence through Quality
| Product Name | Vatalanib Dihydrochloride |
| Description |
VEGFRK inhibitor |
| Purity | 96% |
| CAS No. | 212141-51-0 |
| Molecular Formula | C20H17Cl3N4 |
| Molecular Weight | 419.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (30 mg/ml), ethanol (10 mg/ml) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/ml ) |
| Source | Synthetic |
| Appearance | Solid |
| SMILES | C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl |
| InChI | InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H |
| InChIKey | AZUQEHCMDUSRLH-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Vatalanib Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-484) |
Biological Description
| Alternative Names | N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Growth Factor Receptor Inhibitors |
| PubChem ID | 22386467 |
| Scientific Background | Vatalanib Dihydrochloride is an inhibitor of Flk, c-Kit and PDGFR-β. It has been shown to inhibit VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival. |
| References | 1. Herbst R.S., Heymach J.V., O’Reilly M. S., Onn A., & Ryan A.J. (2007) Expert Opin. Invest. Drugs. 16(2): 239–249. |
Product Images
Chemical structure of Vatalanib Dihydrochloride (SIH-484), a VEGFRK inhibitor. CAS #: 212141-51-0. Molecular Formula: C20H17Cl3N4. Molecular Weight: 419.7 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.