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| Product Name | Vildagliptin |
| Description |
Anti-diabetic agent |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 274901-16-5 |
| Molecular Formula | C17H25N3O2 |
| Molecular Weight | 303.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C1C[C@@H](C#N)N(C1)C(=O)CN[C@]12C[C@@H]3C[C@H](C1)C[C@@](C3)(C2)O |
| InChI | InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12-,13+,14-,16+,17-/m0/s1 |
| InChIKey | SYOKIDBDQMKNDQ-NHMCJKAESA-N |
| Safety Phrases |
Signal Word: Warning GHS Classifcation: GHS07 Acute toxicity (oral, dermal, inhalation), category 4 Skin irritation, category 2 Eye irritation, category 2 Skin sensitisation, category 1 Specific Target Organ Toxicity – Single exposure, category 3 Hazard statement(s): H302 H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P301 + P312 + P330-P305 + P351 + P338 |
| Cite This Product | Vildagliptin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-567) |
Biological Description
| Alternative Names | (S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237 |
| Research Areas | Alzheimer's Disease, Atherosclerosis, Cardiovascular System, Diabetes Associated, Neurodegeneration, Neuroscience |
| PubChem ID | 11077541 |
| Scientific Background | Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1) (1). Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia) (2). It is a clinically useful antidiabetic agent. |
| References |
1. B Balas et al., (2007) J. Clin. Endocrinol. Metab. 92:1249. 2. B Ahren et al., (2004) J. Clin. Endocrinol. Metab. 89:2078. |
Product Images
Chemical structure of Vildagliptin (SIH-567), a Antidiabetic Agent. CAS #: 274901-16-5 . Molecular Formula: C17H25N3O2. Molecular Weight: 303.4 g/mol.
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