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| Product Name | VU0467154 |
| Description |
M4 Receptor Agonist |
| Purity | >98% (HPLC) |
| CAS No. | 1451993-15-9 |
| Molecular Formula | C17H15F3N4O3S2 |
| Molecular Weight | 444.45 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Blue Ice or 4ºC |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO |
| Source | Synthetic |
| Appearance | Tan Solid |
| SMILES | O=S(C1=CC=C(C=C1)CNC(C2=C(N)C 3=C(C)C(C)=NN=C3S2)=O)(C(F)(F)F)= O |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | VU0467154 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-184) |
Biological Description
| Alternative Names | 5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide |
| Research Areas | Neurodegeneration, Neuroscience, Neurotransmitter Receptors, NMDA Receptors |
| PubChem ID | PMC4324418 |
| Scientific Background | Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice. |
| References | 1. Bubser M., et. al. (2014) ACS Clinical Neuroscience 5: 920 - 942. |
Product Images
Chemical structure of VU0467154 (SIH-184), a M4 Receptor Agonist. CAS #: 1451993-15-9. Molecular Formula: C17H15F3N4O3S2. Molecular Weight: 444.45 g/mol.
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Based on validation through cited publications.