WHI P131

JAK3 kinase inhibitor

Catalog No. SIH-485

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CAS No. 202475-60-3
Molecular Formula C16H15N3O3
SKU: SIH-485 Categories: ,

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SIH-485_WHI-P131_Chemical_Structure.png
Product Name WHI P131
Description

JAK3 kinase inhibitor

Purity >98%
CAS No. 202475-60-3
Molecular Formula C16H15N3O3
Molecular Weight 297.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml)
Source Synthetic
Appearance White to off-white solid
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC
InChI InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
InChIKey HOZUXBLMYUPGPZ-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product WHI P131 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-485)

Biological Description

Alternative Names WHI-P131, Janex 1, 4-​[(6,​7-​dimethoxy-​4-​quinazolinyl)amino]-​phenol
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 3794
Scientific Background WHI P131 also known as Janex-1, is a reversible, potent, and specific inhibitor of JAK3. WHI P131 is cell permeable. It has been seen to inhibit glioblastoma cell adhesion and migration, as well as, thrombin-induced platelet aggregation.
References 1. Sudbeck E.A., et al. (1999) Clin. Cancer Res: J. Am. Asso. Cancer Res. 5(6): 1569–1582.

Product Images

<p>Chemical structure of WHI P131 (SIH-485), a JAK3 kinase inhibitor. CAS #: 202475-60-3. Molecular Formula: C16H15N3O3. Molecular Weight: 297.3 g/mol.</p>

Chemical structure of WHI P131 (SIH-485), a JAK3 kinase inhibitor. CAS #: 202475-60-3. Molecular Formula: C16H15N3O3. Molecular Weight: 297.3 g/mol.

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