WP-1130

Name: WP-1130
SKU: SIH-337
Availability: InStock

DUB inhibitor

Catalog No. SIH-337

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CAS No.	856243-80-6
Molecular Formula	C19H18BrN3O

SKU: SIH-337 Categories: Inhibitor, Small Molecules

Product Name	WP-1130
Description	DUB inhibitor
Purity	>98%
CAS No.	856243-80-6
Molecular Formula	C₁₉H₁₈BrN₃O
Molecular Weight	384.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 45 mg/ml DMSO, 25 mg/ml Ethanol
Source	Synthetic
Appearance	Pale Yellow Solid
SMILES	CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
InChI	InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
InChIKey	LIDOPKHSVQTSJY-VMEIHUARSA-N
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	WP-1130 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-337)

Alternative Names	(2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
Research Areas	Apoptosis, Cancer
PubChem ID	11222830
Scientific Background	A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Blocks Jak2 signaling via Jak2 ubiquitination.
References	1. KapuriaV., et al. (2010) Cancer Res. 70: 9265. 2. Kapuria V., et al. (2011) Cell Signal. 23: 2076.

Chemical structure of WP-1130 (SIH-337), a DUB inhibitor. CAS #: 856243-80-6. Molecular Formula: C19H18BrN3O. Molecular Weight: 384.3 g/mol.

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