Discovery through Partnership | Excellence through Quality
| Product Name | YM-58483 |
| Description |
CRAC channel blocker |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 223499-30-7 |
| Molecular Formula | C15H9F6N5OS |
| Molecular Weight | 421.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Blocker |
| Solubility | May be dissolved in DMSO (40 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F |
| InChI | 1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27) |
| InChIKey | XPRZIORDEVHURQ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | YM-58483 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-606) |
Biological Description
| Alternative Names | N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; BTP2 |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Neurotransmission |
| PubChem ID | 2455 |
| Scientific Background | YM-58483 is a calcium release-activated calcium channel blocker. It inhibits antigen-induced histamine release via modulation of mast cell responses. It also is a potent T-cell antiproliferative agent. |
| References |
1.,Zitt. C., et al. (2004) J. Biol. Chem. 279(13): 12427-12437. 2.,Law M., et al. (2001) Int. J. Biochem. Cell Biol. 43:1228-1239. 3.,K Ohga et al. (2008) Int. Immunopharmacol. 8:1787-1792. |
Product Images
Chemical structure of YM-58483 (SIH-606), a CRAC channel blocker. CAS #: 223499-30-7. Molecular Formula: C15H9F6N5OS . Molecular Weight: 421.3 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.