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| Product Name | ZM 306416 |
| Description |
VEGFR kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 690206-97-4 |
| Molecular Formula | C16H13ClFN3O2 |
| Molecular Weight | 333.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (3 mg/ml) or ethanol (1 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC |
| InChI | InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21) |
| InChIKey | YHUIUSRCUKUUQA-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | ZM 306416 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-487) |
Biological Description
| Alternative Names | ZM-306416 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5329006 |
| Scientific Background | ZM 306416 is a potent and selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, particularly Flk-1 (KDR) and Flt. In neuroscience, ZM 306416 is used to explore the role of VEGF signaling in neurovascular function, blood-brain barrier integrity, and neuroinflammation. Its ability to modulate angiogenic pathways makes it a useful tool in studying neurovascular contributions to neurodegenerative diseases such as Alzheimer’s and multiple sclerosis. |
| References |
1. Hennequin L.F., et al. (1999) J. Med. Chem. 42(26): 5369–5389. 2. Kawai, T., et al. (2006) Neurosci. 141(3): 1209–1216. |
Product Images
Chemical structure of ZM 306416 (SIH-487), a VEGFR kinase inhibitor. CAS #: 690206-97-4. Molecular Formula: C16H13ClFN3O2. Molecular Weight: 333.7 g/mol.
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