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| Product Name | ZM 336372 |
| Description |
c-Raf kinase inhibitor |
| Purity | >95% (HPLC) |
| CAS No. | 208260-29-1 |
| Molecular Formula | C23H23N3O3 |
| Molecular Weight | 389.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (200 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O |
| InChI | InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28) |
| InChIKey | PYEFPDQFAZNXLI-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 5) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H303 May be harmful if swallowed. |
| Cite This Product | ZM 336372 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-488) |
Biological Description
| Alternative Names | N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5730 |
| Scientific Background | ZM 336372 is a potent, specific and reversible inhibitor of the protein kinase c-Raf. It has also been shown to inhibit SAPK2/p38. ZM 336372 is cell permeable. |
| References | 1. Hall-Jackson C.A., et al. (1999) Chem. Biol. 6(8): 559–568. |
Product Images
Chemical structure of ZM 336372 (SIH-488), a c-Raf kinase inhibitor. CAS #: 208260-29-1. Molecular Formula: C23H23N3O3. Molecular Weight: 389.4 g/mol.
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